Genetic Basis of Mitral Valve Prolapse
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 1,500
- 试验地点
- 1
- 主要终点
- Discovery of the genetic basis of Mitral Valve Prolapse
研究概览
简要总结
The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.
详细描述
This is a genome-wide association study.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Mitral valve prolapse
排除标准
- •Other mitral valve diseases
结局指标
主要结局
Discovery of the genetic basis of Mitral Valve Prolapse
时间窗: 5 years
Genome-wide association
次要结局
未报告次要终点
研究者
Robert A. Levine, MD
Cardiologist
Massachusetts General Hospital