Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- Awakening Time
研究概览
简要总结
It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia. The investigators hypothesized that using desflurane with target controlled infusion of remifentanil is more effective than using desflurane alone during deep extubation. The purpose of this study is to evaluate the effect of remifentanil to prevent respiratory complication (etc. coughing) during emergence from general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 20-60
- •patients undergoing elective surgery take more than an hour
- •Under general anesthesia using an LMA
排除标准
- •Patients on CNS depressants
- •Chronic opioid use
- •Corticosteroid
- •Pregnant patients
- •Full stomach
- •Morbidly obese (BMI >35kg/m2)
- •Hepatitis B
- •Hepatitis C
- •Coronary artery disease
- •Liver disease
- •Renal disease
- •Seizure disorder
- •Dropout criteria:
- •Need for reintubation due to breath holding
- •high ETCO2 during self ventilation (ETCO2>50)
- •Surgeon or patient request
研究组 & 干预措施
Desflurane group
1.5 MAC desflurane until extubation
干预措施: Desflurane (Drug)
Desflurane with remifentanil group
1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil
干预措施: Desflurane with remifentanil (Drug)
结局指标
主要结局
Awakening Time
时间窗: Participants will be followed from the time of extubation in operating room to the time of discharge from recovery room, an expected average of 1day.
The outcomes assessor will record from the time of extubation in operating room to the time of eye opening and mouth opening
次要结局
- Success Rate & Complication Rate Including Cough(assessing the success rate of deep extubation without complication and the occurrance of cough from the completion of surgery to 5minute after extubation.)
研究者
Chongwha Baek
Chongwha Baek, MD, Ph.D
Chung-Ang University Hosptial, Chung-Ang University College of Medicine