Effect of Physical Strength Exercise on Telomeric Length as a Marker of Aging and Early Death in Patients With Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Telomere Length
研究概览
简要总结
Randomised clinical trial on a cohort of subjects with a diagnosis of schizophrenia of legal age, of both sexes, recruited in the mental health clinics of the Salamanca University Assistance Complex and who will be randomly distributed into two groups (intervention and control).
The main objective of the study is to determine the effect of physical exercise on telomere size in patients diagnosed with schizophrenia.
As secondary objectives in this group of patients we will try to:
Evaluate the influence of strength training on cognition and negative symptoms of schizophrenia.
To quantify the impact of strength training on frailty. To determine the effect of strength training on quality of life. To study the possible correlation between physical parameters (frailty) and telomere length.
To establish the importance of polymorphisms in telomerase genes, an enzyme involved in the maintenance of telomere length.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Single (Outcomes Assessor)
盲法说明
The persons in charge of the evaluation of the participants will be unaware of the assignment of the participants.
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •be at least 18 years of age
- •have been diagnosed with schizophrenia for at least 5 years
排除标准
- •are unable to read and understand the patient information sheet and sign the informed consent form.
研究组 & 干预措施
Intervention group
An additional strength training programme will be carried out for 12 weeks with 2 sessions per week. The sessions will last approximately 50 minutes and will be divided into 3 distinct parts: The first part will consist of a warm-up with a part of aerobic exercise that will last approximately 15 minutes. This will be followed by the main part of strength training with a circuit of 6 exercises (3 series x 12 repetitions) which will last approximately 25 minutes.
Finally, there will be a cool down phase with breathing exercises to allow people to recover.
干预措施: Strength physical exercise programme (Other)
Control group
Subjects in the control group will continue with their normal life and carry out all the activities they have been doing previously.
干预措施: Normal life (Other)
结局指标
主要结局
Telomere Length
时间窗: Baseline and immediately after the intervention
Telomere length will be measured before and after the procedure in kilobases.
次要结局
- Sex(Baseline)
- Cognition(Baseline and immediately after the intervention)
- Fragility(Baseline and immediately after the intervention)
- Date of birth(Baseline)
- Quality of life(Baseline and immediately after the intervention)
- Heighth(Baseline)
- Negative Symptoms(Baseline and immediately after the intervention)
研究者
Juan Luis Sanchez Gonzalez
Principal Investigator. Juan Luis Sánchez González
University of Salamanca