Efficacy and Antimicrobial Activity of Platelet Rich Plasma (PRP) in Acne Vulgaris : A Randomized Controlled Trial
试验速览
- 阶段
- 3 期
- 入组人数
- 50
- 主要终点
- Cure rate
研究概览
简要总结
Efficacy and Antimicrobial activity of Platelet Rich Plasma (PRP) in Acne Vulgaris : A randomized controlled trial
详细描述
Acne vulgaris is one of the most common chronic skin diseases worldwide. The condition usually starts in adolescence, peaks at the ages of 14 to 19 years and frequently resolves by mid-twenties.
Acne is characterized by seborrhea, formation of open and closed comedones, erythematous papules and pustules and in more severe cases present with nodules, deep pustules and pseudo cysts, in many cases a degree of scarring will ensue.
Its pathophysiology includes hyperseborrhoea, abnormal follicular keratinization and Propionibacterium acnes proliferation in the pilosebaceous unit.
Acne is a significant clinical problem with sever social, psychological, and emotional implications. A mainly genetically determined host response pattern combined with bacterial ''triggering'' is generally accepted as being important for the apparently unbalanced inflammatory activity.
Acne is not an infectious disease, but three major organisms were isolated from the surface of the skin and the pilosebaceous duct of patients with acne including Propionibacterium acne, Staphylococcus epidermidis and Malassezia furfur.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 14 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with active acne vulgaris lesions (inflammatory and non-inflammatory).
- •Age range from 14 to 40 years.
- •Patients with any topical and systemic treatments will undergo wash out period of one month.
排除标准
- •Patients with herpes labials, or bacterial infection; warts on the face, actinic keratosis, or skin cancer or allergy to medications.
- •Systemic retinoids intake in the previous 6 months
- •History of keloidal scarring.
- •Patients on anticoagulant therapy or aspirin or have a coagulation issue,
- •Patients with hemoglobin less than 10g\dl or platelet less than 105 micron\l
- •Pregnant women
- •Immunocompromised patients
- •Patients with medical diseases like diabetes mellitus, epilepsy or malignancy
研究组 & 干预措施
Chemical peeling (Salycilic acid)
干预措施: Chemical peeling (Salycilic acid) (Other)
Chemical peeling (Jessenr's solution)
干预措施: Chemical peeling (Jessener's solution) (Other)
PRP
干预措施: PRP (Combination Product)
结局指标
主要结局
Cure rate
时间窗: 3 months
Assess cure rate of PRP and Chemical peeling agents in treatment of Aactive Acne Vulgaris in 3 months duration and compare efficacy of all measures
次要结局
未报告次要终点
研究者
Hiba A H alshaaby
Principal investigator
Assiut University