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临床试验/NCT03394274
NCT03394274已完成不适用

Restrictive Versus Liberal Transfusion for Elective Major Surgery and Perioperative Outcomes: Mortality, Morbidity and Requirement of Postoperative Blood Transfusion

Leyla Kılınc1 个研究点 分布在 1 个国家目标入组 892 人开始时间: 2017年6月14日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
892
试验地点
1
主要终点
Restrictive or Liberal transfusion

研究概览

简要总结

Investigators aimed to compare the restrictive and liberal blood transfusion methods applied in major surgical operations performed in Anesthesiology and Reanimation Clinic and investigate their effects on postoperative transfusion needs, morbidity and mortality.

详细描述

The test subjects consisted of 892 patients, who belong to ASA (American society of Anesthesiology) I -IV groups, underwent elective major surgery between the 01/01/2016-31/12/2016, and are over the age of 18 years. The demographic data (Age, sex, ASA (American society of Anesthesiology) scors, surgery type) were also recorded. we evaluated the value of Hemoglobin, platelet, APTT (activated partial thromboplastin time), INR (international normalized ratio) preoperatively and postoperatively. In this study, restrictive and liberal blood transfusion groups were investigated.restrictive and liberal transfusion hemoglobin threshold value respectively before perioperative transfusion was 8 g / dL. were defined as restrictive blood transfusion group and perioperative transfusion was over 8 g / dL were defined as liberal blood transfusion group. Adverse events (tachycardia, hypotension, the value of lactate and metabolic acidosis). Postoperatively, the amount of postoperative transfusion unit, duration of hospital stay, requirement of intensive care unit and mortality rate.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Over 18 years old patients,
  • ASA I-II-III-IV,
  • Major surgeries ( Intra-abdominal, intracranial, head and neck malignancy surgery, femur and vertebra surgery)

排除标准

  • Emergency operation,
  • Cardiovascular surgery,
  • Under 18 years old patients

结局指标

主要结局

Restrictive or Liberal transfusion

时间窗: 52 weeks

It is determined how many units of RBC (red blood cell ) used during major operations at the hospital in liberal transfusion group or restrictive transfusion group.

次要结局

  • Postoperative transfusion requirement(52 Weeks)
  • Postoperative Duration of Stay in Hospital of patients(52 Weeks)
  • Mortality(52 weeks)
  • The Need of ICU(52 Weeks)

研究者

发起方
Leyla Kılınc
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Leyla Kılınc

medical doctor, anesthesiology specialist

Sisli Hamidiye Etfal Training and Research Hospital

研究点 (1)

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