DEXTROSE 5% VERSUS NORMAL SALINE AS MAINTENANCE FLUID THERAPY IN PATIENTS WITH SEPTIC SHOCK; A RANDOMIZED CONTROLLED TRIA

faculty of medicine Alexandria university0 个研究点目标入组 100 人开始时间: 2022年6月21日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•?Septic shock defined as sepsis with persisting hypotension requiring vasopressors to maintain MAP = 65 mm Hg and having a serum lactate level >2 mmol/L (18 mg/dL) despite adequate volume resuscitation.
•?Age = 18 years.
•?Need for maintenance fluid as determined by the treating clinician
•?Study intervention can be administered within 1 h of inclusion criteria being met.

•?Clinical situations that would render the primary endpoint difficult to interpret:
•Chronic diuretic or decompression use.
•Liver failure.
•Treatment with parenteral feeding.
•Confirmed or suspected pregnancy.
•Patients in whom death is considered imminent (within 24 hours)
•?Potential patient harm by the study fluids:
•Severe heart failure.
•Patients with intracranial pathology (eg; traumatic brain injury, Stroke).
•Electrolyte disorders;
•?A sodium level below 130 mmol/L or over 150 mmol/L or
•?A potassium level below 3 mmol/L or over 5 mmol/L

发起方