Dextrose saline versus saline solution infused for the initial rehydration of hyperemesis gravidarum

Not Applicable

Completed

• Conditions: Hyperemesis gravidarum; Pregnancy and Childbirth; Hyperemesis gravidarum with metabolic disturbance

• Registration Number: ISRCTN65014409
• Lead Sponsor: niversity of Malaya (Malyasia)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-05-16
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

1. Clinical hyperemesis gravidarum with dehydration
2. Age = 18 years
3. Pregnancy less than 16 weeks of gestation
4. A positive urine pregnancy test if pregnancy not confirmed by ultrasound
5. Urine ketone at least 1+ on admission
6. First admission for hyperemesis gravidarum in current pregnancy
7. Venous plasma glucose = 6 mmol/l
8. Venous sodium = 125 mmol/l

Exclusion Criteria

1. Molar pregnancy
2. Women with underlying medical problem eg established gestational hypertension, diabetes, heart disease, renal disease, thyroid disorder
3. Suspected gastrointestinal causes of nausea and vomiting e.g. gastritis, gastroenteritis, peptic ulcer
4. Established non viable pregnancy
5. Preexisting medical condition that can cause or exarcebate nausea and vomiting (eg culture proven symptomatic urinary tract infection, dengue fever)

Study & Design

• Study Type: Interventional
• Study Design: Not specified