The effectiveness of dextrose prolotherapy in knee osteoarthritis; The effectiveness of genicular nerve block in knee osteoarthritis

Not Applicable

Conditions: Knee Osteoarthritis
Dextrose Prolotherapy
Genicular Nerve Block.

Registration Number: IRCT20201013049018N1

Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 30

Inclusion Criteria

Existence of pain and other clinical signs of knee osteoarthritis and pain with a VAS score of at least 4 due to knee osteoarthritis during last month
Age between 45 to 70 years old
Absence of any periarticular disease around the target joint

Exclusion Criteria

Diabetes Mellitus
Rheumatologically and collagen vascular disorders (eg; gout and lupus)
Radiculopathy
Nerve injuries and neuropathy
Brucellosis
BMI more than 42
Knee replacement on the affected side
History of trauma and joint fracture
Severe deformity of the lower extremities
Bleeding disorders
Inability to communicate
History of allergic reactions to the used drugs
History of intraarticular or periarticular injections at the affected joint in the last 3 months
History of significant liver, kidney and cardiopulmonary disorders
Pregnancy
Malignancy
Use of anticoagulants

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain due to knee osteoarthritis. Timepoint: Before starting the intervention; 2, 4, 8, &12 weeks later. Method of measurement: Visual analog scale; Western Ontario and McMaster Universities Arthritis Index; Oxford knee scale; Patient satisfaction.

Secondary Outcome Measures

Name	Time	Method
Patient function. Timepoint: Before starting the intervention; 2, 4, 8, &12 weeks later. Method of measurement: Visual analog scale.;Patient function. Timepoint: Before starting the intervention; 2, 4, 8, &12 weeks later. Method of measurement: Western Ontario and McMaster Universities Arthritis Index.;Patient function. Timepoint: Before starting the intervention; 2, 4, 8, &12 weeks later. Method of measurement: Oxford knee scale.