Acute Longitudinal Transcranial Magnetic Stimulation (TMS) After Stroke
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 5
- 试验地点
- 1
- 主要终点
- navigated transcranial magnetic stimulation examination and correlation with motor functional testing
研究概览
简要总结
The past 10 years of research in persons more than 6 months post stroke have shown certain types of rehabilitation can help "re-wire" the brain. Transcranial magnetic stimulation (TMS) can be used to monitor this re-wiring by mapping the brain's function (measuring brain activity). Recent research suggests that TMS can be used for both prognosis (determining future function) and to determine what type of rehabilitation therapy will work best after stroke. The purposes of this research study are to: 1) determine changes in brain activity during the first 6 months after stroke (to determine how the brain "re-wires"); 2) compare changes in recovery of motor function with changes in brain re-wiring; 3) determine the ability of TMS to "predict" functional outcome in the first 6 months after stroke.
The primary hypotheses are: 1) functional recovery will be correlated with TMS changes (as measure motor threshold (MT), motor evoked potentials (MEPs) and recruitment curves; 2) baseline TMS will predict future functional outcomes at 3 and 6 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •one sided ischemic stroke confirmed by radiology
- •20-80 years old
排除标准
- •hemorrhagic stroke
- •brainstem stroke
- •cerebellar stroke
- •thalamic stroke
- •seizure with the recent stroke
- •any history of uncontrolled seizure
- •history of epilepsy
- •pregnancy or planning on getting pregnant during the next year
- •MRI incompatibility (e.g. metal implants in body)
- •recent history (past year) of alcohol and drug abuse (due to lack of follow up)
- •Other criteria include TMS exclusions: aneurysm clips, previous surgery over motor cortex, open craniotomy
结局指标
主要结局
navigated transcranial magnetic stimulation examination and correlation with motor functional testing
时间窗: Enrollment, week 2, week 4 , week 12 and week 24 post-stroke
次要结局
- Safety of navigated transcranial magnetic stimulation examination(each examination)