Comparing Phenotypic and Autonomic Physiologic Determinants of Neurocardiogenic Syncope
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Autonomic data respiratory sinus arrhythmia among patients with chest pain
研究概览
简要总结
This is a prospective observational pilot study of suitability of autonomic monitoring via the VU-AMS device for prediction of neurocardiogenic syncope (NCS) in children referred to cardiopulmonary exercise testing (CPET) for a diagnosis of syncope. The study population is children referred for CPET to evaluate for neurocardiogenic syncope. The purpose is to describe autonomic function during rest and exercise and determine the positive predictive value of autonomic function measurements against the gold standard for diagnosis of neurocardiogenic syncope, the CPET. Children presenting for CPET with chest pain or who are status post orthotopic heart transplantation will serve as positive and negative controls respectively.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 24 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Parent/Legal guardian able to provide informed consent
- •Verbal participant assent
- •Undergoing clinically indicated CPET.
- •Diagnosis of either syncope, chest pain/dyspnea or status post OHT
- •Participant willing and able to participate in study procedures
- •Age 7-24 years
排除标准
- •Participant unwilling or unable to participate
- •Contraindication to adhesive placement, eg, epidermolysis bullosa
- •Cancellation of the subject's planned CPET procedure.
- •Tracheostomy tube presence (this will prevent proper placement of impedance cardiogram lead)
结局指标
主要结局
Autonomic data respiratory sinus arrhythmia among patients with chest pain
时间窗: Data collected throughout cardiopulmonary exercise testing. Up to 90 minutes.
Subjects will wear an ambulatory monitor during testing
Autonomic data respiratory sinus arrhythmia among patients post heart transplant
时间窗: Data collected throughout cardiopulmonary exercise testing. Up to 90 minutes.
Subjects will wear an ambulatory monitor during testing
Autonomic data respiratory sinus arrhythmia among patients with syncope
时间窗: Data collected throughout cardiopulmonary exercise testing. Up to 90 minutes.
Subjects will wear an ambulatory monitor during testing
次要结局
未报告次要终点