Comprehensive Risk Assessment of People With Silicosis: A Population-based Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 390
- 试验地点
- 1
- 主要终点
- Body mass index
研究概览
简要总结
Objectives: This study aims to explore the risk profiles among people with silicosis in Hong Kong underpinned by the Pittsburgh Mind-Body Center model.
Design and subjects: This study will adopt a cross-sectional study design with sampling stratified by participants' degree of incapability. 320 Chinese people diagnosed with silicosis and registered with the Pneumoconiosis Compensation Fund Board will be recruited.
Data collection: A demographic data sheet and the St. George's Respiratory Questionnaire will be used to collect the socio-demographic and clinical characteristics of the participants. The behavioral factors (smoking, drinking, physical activity level, consumption of vegetable and fruits and plasma vitamin C level) as well as the psychological risk factors (anxiety and depressive symptoms, and social support) will be examined by validated questionnaires. Biological and physiological parameters, including insulin resistance, C-reactive protein, hemoglobin, fasting blood glucose and lipid profiles, will be ascertained by fasting blood sample.
Data analysis and expected outcomes: The findings of this study will create the database profile of the physical, psychosocial and disease specific aspects among people with silicosis in Hong Kong, subsequently forming the empirical basis of an intervention to tackle the identified modifiable risks among them.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hong Kong Chinese-speaking residents and Chinese ethnicity;
- •diagnosis of silicosis and confirmed by the Pneumoconiosis Medical Board
- •registered with the Pneumoconiosis Compensation Fund Board (PCFB); and
- •able and willing to give informed written consent
排除标准
- •With medically diagnosed mental illness, including major depression, or
- •with active pulmonary tuberculosis
结局指标
主要结局
Body mass index
时间窗: baseline
BMI in kg/m\^2
waist circumference
时间窗: baseline
WC in cm
Respiratory symptoms and related physical limitation
时间窗: baseline
examined by Hong Kong Chinese version of St. George's Respiratory Questionnaire
Psychological status
时间窗: baseline
Anxiety and depression symptoms measured by the Chinese version of Hospital Anxiety and Depression Scale
Quality of life
时间窗: baseline
examined by the SF-12v2
Social support
时间窗: baseline
measured by the Chinese version of six-item Social Support Questionnaire
12 hour fasting ascorbic acid level
时间窗: baseline
vit-C in mg/dL
fasting high sensitivity C-reactive protein level
时间窗: baseline
hs-CRP in mg/L
12-hour fasting lipid profile
时间窗: baseline
total-cholesterol, HDL-Cholesterol, LDL-cholesterol and triglycerides (in mmol/L)
12-hour fasting glucose
时间窗: baseline
FG in mmol/L
fasting insulin level
时间窗: baseline
insulin in pmol/L
hemoglobin level
时间窗: baseline
hemoglobin in g/dL
smoking and drinking habits, vegetable and fruit intake
时间窗: baseline
questions adopted from the Behavioral Risk Factor Surveillance of the Department of Health, Hong Kong SAR
Physical activity level
时间窗: baseline
measured by the International Physical Activity Questionnaire - Short Form
次要结局
未报告次要终点
研究者
Ho Yu CHENG
post-doctoral fellow
Chinese University of Hong Kong