Assessment of Human Exposure to Chemical Hazards

Recruiting

• Conditions: Dietary Exposure
• Interventions: Other: Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection

• Registration Number: NCT06526169
• Lead Sponsor: National University of Singapore

Brief Summary

The aim of this study is to evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption.

Detailed Description

Human biomonitoring is an exposure assessment approach with the potential value-add supplementation to existing sources of information for regulatory risk assessments and for supporting food safety policies. The collaboration involving academic partners from the sciences and public health disciplines to quantify the in vivo chemical exposure of chemicals will take reference from the findings in the Singapore's total diet study on the prioritised chemical hazards of interest for a more precise assessment of the distribution of risk in the population. Direct measurement of chemicals and/or metabolites in biological specimens obtained from study subjects will be conducted to provide a more comprehensive understanding on the baseline dietary chemical exposure in the local population. Dietary assessment using food frequency questionnaire will be administered to the same group of study subjects to associate human exposure to chemical hazards with food consumption across the different population groups in Singapore.

Study Timeline

• Status Verified: 2024-07
• Study First Submitted: 2024-07-24
• Study First Submitted QC: 2024-07-24
• Study First Posted: 2024-07-29
• Study Start: 2024-08-21
• Last Update Submitted: 2024-11-13
• Last Update Posted: 2024-11-15
• Primary Completion: 2027-07-31
• Study Completion: 2027-07-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Must be English-literate and able to give informed consent in English
• 21 to 60 years of age (inclusive) at screening
• Healthy adults
• Race must be Chinese or Indian or Malay
• Reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures

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Exclusion Criteria

• Known or ongoing psychiatric disorders within 3 years
• Being diagnosed with cancer, heart disease, stroke, renal failure, serious mental or physical illnesses at the time of recruitment
• Have donated blood of more than 500 mL within 4 weeks of study enrolment

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Ethnicity: Chinese	Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection	-
Ethnicity: Malay	Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection	-
Ethnicity: Indian	Food Frequency, Social, Lifestyle, Demographic Questionnaires and Blood Collection	-

Primary Outcome Measures

Name	Time	Method
Chemical hazards occurrence	3 years	To evaluate the occurrence of chemical hazards exposure in the Singapore population and assess their association with food consumption.

Trial Locations

Locations (2)

National University of Singapore, Department of Food Science & Technology; 🇸🇬 Singapore, Singapore

National University of Singapore; 🇸🇬 Singapore, Singapore