The Medical Management in Patients Exposed to Weapons of Mass Destruction

• Conditions: Acute Respiratory Distress Syndrome; Distress Respiratory Syndrome; Chemical Injury; Medical Emergencies; Chemicals; Intoxication

• Registration Number: NCT05026645
• Lead Sponsor: St. Justine's Hospital

Brief Summary

Observation study measuring medical response in contaminated environment.

Detailed Description

This is an ongoing multicentric observational study that aims to assess the medical response to chemical, biological, radiological, nuclear, explosive (cbrne) events during the last five (5) decades (i.e.: 1970-2020), and in any future cbrne attack that might occur within the next 15 years (i.e.: 2021-2036). Of note, the data collection will be performed retrospectively and after sites review ethic board (REB) approval.

Study Timeline

• Study Start: 2020-10-01
• Study First Submitted: 2021-08-18
• Study First Submitted QC: 2021-08-23
• Study First Posted: 2021-08-30
• Status Verified: 2025-07
• Last Update Submitted: 2025-07-11
• Last Update Posted: 2025-07-15
• Primary Completion: 2036-11-01
• Study Completion: 2036-12-01

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

i. a CBRNE attack caused at least one casualty who required the assistance of the participating health care system (e.g.: physicians, nurses, paramedics and other health-care specialists of a medical facility) during a medical extraction from the incident site until admission to a medical facility;

ii. Patients are eligible if they were exposed to the CBRNE attack;

iii. Medical information concerning the CBRNE exposures, even if partial, is accessible to health care professionals for the purposes of filling out the online case report form (eCRF);

iv. Participants must be able to complete the online case report form in English; and

v. The approval of an Ethics Review Board is obtained by each medical centre participant.

Exclusion Criteria

A negative response to any of the inclusion criteria results in an exclusion.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Intervention and location	At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).	The percentage of patients to whom the World Health Organization's healthcare guidelines were applied without any delay (i.e.: during a medical extraction/evacuation)

Secondary Outcome Measures

Name	Time	Method
Contamination under-control due to efficient decontamination measures applied during a medical extraction/evacuation	At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).	The percentage of patients whose health condition remained stable during a medical extraction due to efficient WHO's decontamination measures applied
Contamination is under-control due to efficient protective measures applied during a medical extraction/evacuation	At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).	The percentage of patients whose health condition remained stable during a medical extraction due to efficient WHO's protective measures applied
Deterioration of the patient's health condition due to compromised means of decontamination	At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).	The percentage of patients whose health condition deteriorated during a medical extraction due to the misuse of WHO's decontamination measures (e.g.: immediate (roughly) or/and thorough (specialized one)).
Deterioration of the patient's health condition due to compromised means of protection	At the patient's admission at the hospital emergency room (i.e.: end-point of the medical extraction/evacuation).	The percentage of patients whose health condition deteriorate during a medical extraction due to the misuse of WHO's protective measures (e.g.: mask, suit, gloves, boots, etc).

Trial Locations

Locations (15)

Director, Unconventional Weapons & Technology Division, National Consortium for the Study of Terrorism and Responses to Terrorism University of Maryland; 🇺🇸 College Park, Maryland, United States

Centre for Defence and Security Studies, University of Manitoba; 🇨🇦 Winnipeg, Manitoba, Canada

Royal Canadian Medical Corps; 🇨🇦 Ottawa, Ontario, Canada

Research Center of the CHU St-Justine, University of Montreal; 🇨🇦 Montreal, Quebec, Canada

École de Technologie Supérieure Université du Québec; 🇨🇦 Montréal, Quebec, Canada

Biomedical Telematics Laboratory Platform of the Quebec Respiratory Health Research Network; 🇨🇦 Sherbrooke, Quebec, Canada

Research Centre, Quebec Heart and Lung Institute, Laval University; 🇨🇦 Quebec, Canada

Medical Intelligence CBRNE Inc.; 🇨🇦 Quebec, Canada

University of Finance and Administration Department of Criminology and Forensic Disciplines; 🇨🇿 Prague, Czechia

Sorbonne University; 🇫🇷 Paris, ile de France, France

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