Remember NIBS? tACS Improves Memory Performance in Elders With Subjective Memory Complaints
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 2
- 主要终点
- Change in performance
研究概览
简要总结
Subjective memory complaints (SMC), the main cognitive component of which is event memory, is a predictor of Alzheimer's disease in elderly people. The purpose of this study was to investigate the effect of transcranial alternating current stimulation (tACS) with theta frequency (6 Hz) on the medial prefrontal cortex in the improvement of episodic memory in individuals with SMC in a double blind, randomized, and sham-controlled parallel study. Sixteen participants with SMC received either active or sham theta tACS on the medial prefrontal cortex (mPFC). EEG was recorded and Rey Auditory Verbal Learning Test (RAVLT) was administered. The aim of the current study was to see if theta tACS over the mPFC can improve event memory in individuals with SMC and thus can be considered a potential therapeutic intervention for this population or not.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Being 50 or older,
- •Mini Mental State Examination (MMSE) grade from 27 to 30
- •Total score of 58 or more on the Everyday Memory Questionnaire (EMQ)
- •no indications of depression and anxiety measured by Geriatric Depression Scale (GDS) and State-Trait Anxiety Inventory (STAI)
- •No sign of dementia based on Diagnostic and statistical manual of mental disorder, 5th edition (DSM-V) criteria
排除标准
- •History of a major psychological or neurological condition
- •History of head trauma leading to unconsciousness,
- •Presence of metal in the head
- •History of seizures
- •Serious cardiovascular disease
- •Use of medications with an impact on cognitive functions
- •Recent use of alcohol or substance abuse
结局指标
主要结局
Change in performance
时间窗: 25 minutes i.e., before versus after the stimulation
Rey auditory-verbal learning test (RAVLT)
次要结局
- Change in EEG power in theta frequency band(30 minutes, i.e., before versus after stimulation)
- Change in phase synchronization connectivity in theta frequency band(30 minutes, i.e., before versus after stimulation)
研究者
reza kazemi
Assistant professor
University of Tehran