The Effect of Acute Ketone Monoester Supplementation on Glucose Oxidation During Exercise Performed With High Rates of Carbohydrate Ingestion in Trained Cyclists
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 27
- 试验地点
- 2
- 主要终点
- Exogenous carbohydrate oxidation rate
研究概览
简要总结
The purpose of this study is to examine the effect of exogenous ketone body supplementation on carbohydrate metabolism during exercise. In a randomized, crossover, and double-blind study, 20 endurance trained adult males and females aged 18-50 years, will ingest carbohydrates with either a ketone monoester supplement before and throughout a 3-hour exercise session or carbohydrates with a flavour-matched ketone-free placebo. The main aim of this study is to compare the exogenous carbohydrate oxidation rates during exercise between the ketone monoester and placebo conditions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Color and flavor matched placebo
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-50 years of age
- •Trained cyclist/triathlete (VO2peak > 55 ml/kg/min for males and >48 ml/mg/min for females)
- •Healthy as per medical history and investigator's/physician's judgement
- •Having given written informed consent
排除标准
- •Use of medication that could impact study outcomes and/or interfere with the expected mechanism of action of ketone supplements (e.g. Chronic use of gastric acid suppressing medication, statins, corticosteroids)
- •Diagnosed acute or chronic medical conditions that, in the opinion of the investigator, could impact study outcomes (e.g. Diabetes mellitus)
- •Diagnosed musculoskeletal disorders
- •Adhering to a carbohydrate restrictive diet
- •Participation in another study at the same time
- •Blood donation in the 2 months before the first experimental trial
- •Plasma donation in the 2 weeks before the first experimental trial
- •Males: VO2peak <55 ml/min/kg body mass
- •Females: VO2peak <48 ml/min/kg body mass
- •Females: pregnancy
结局指标
主要结局
Exogenous carbohydrate oxidation rate
时间窗: Acute:during 3 hours of exercise
Exogenous carbohydrate oxidation rate during exercise measured by 13C enrichment in breath. CHO+KETONE vs CHO+PLACEBO condition
次要结局
- Endogenous carbohydrate disappearance rate(Acute:during 3 hours of exercise)
- Exogenous carbohydrate disappearance rate(Acute:during 3 hours of exercise)
- Total carbohydrate disappearance rate(Acute:during 3 hours of exercise)
- Exogenous carbohydrate appearance rate(Acute:during 3 hours of exercise)
- Endogenous carbohydrate appearance rate(Acute:during 3 hours of exercise)
- Total carbohydrate appearance rate(Acute:during 3 hours of exercise)
- Plasma glucose enrichments during exercise(Acute:during 3 hours of exercise)