Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- genes involved in the various cell activation and signalling pathways
研究概览
简要总结
Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •FOR PATIENTS WITH SCLERODERMA :
- •Person who has given written consent
- •Person with systemic scleroderma
- •FOR CONTROL PARTICIPANTS :
- •Person who has given written consent
- •Person undergoing plastic, cosmetic and reconstructive surgery
排除标准
- •FOR PATIENTS WITH SCLERODERMA :
- •Person not affiliated to or not benefiting from a social security scheme
- •Person subject to a legal protection measure (curatorship, guardianship)
- •Person subject to a legal protection measure
- •An adult who is incapable or unable to give consent
- •FOR CONTROLLED PARTICIPANTS :
- •Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases
- •Person not affiliated to or not benefiting from a social security scheme
- •Person under legal protection (curatorship, guardianship)
- •Person subject to a legal protection measure
- •An adult who is incapable or unable to give consent
研究组 & 干预措施
Control
People undergoing plastic, cosmetic and reconstructive surgery
干预措施: Analysis of fibroblasts (Other)
Control
People undergoing plastic, cosmetic and reconstructive surgery
干预措施: Skin samples (Procedure)
scleroderma
People with systemic scleroderma
干预措施: Skin samples (Procedure)
scleroderma
People with systemic scleroderma
干预措施: Analysis of fibroblasts (Other)
结局指标
主要结局
genes involved in the various cell activation and signalling pathways
时间窗: through study completion, an average of 12 months
number and type of genes involved in different cell activation and signalling pathways, including senescence, which will be differentially expressed in fibroblasts from the skin of control participants and those from the skin of subjects with SSc.
次要结局
未报告次要终点