NCT01490346已完成不适用
A Compartmental Analysis of HIV Reservoirs and Immune Reconstitution
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- Intracellular antiretroviral drug concentrations
研究概览
简要总结
The aim of this study is to find out why HIV continues to make copies in people taking HIV drugs. The investigators want to know if the medications most people use to treat HIV get into the lymphatic tissue where HIV persists.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Treatment naive or >30 days off ARV therapy
- •Documented sensitivity to prescribed antiretrovirals
- •Age ≥ 18 years
- •Negative pregnancy test for eligible women of childbearing potential
- •Ready to start ARV therapy
排除标准
- •Contraindications to surgical & endoscopy procedures (as judged by PI)
- •Psychiatric or psychological illness that would make adherence to protocol procedures unlikely
- •Pregnancy
研究组 & 干预措施
ART treated individuals
干预措施: Initiation of anti-retroviral therapy (Drug)
结局指标
主要结局
Intracellular antiretroviral drug concentrations
时间窗: Measured at baseline, 1 week, 2 weeks, 1 month, 2 months, 3 months, 4 months, 5 months & 6 months
次要结局
- Evidence of HIV replication in blood and lymphoid tissue(Measured at baseline, 1 week, 2 weeks, 1 month, 2 months, 3 months, 4 months, 5 months, & 6 months)
研究者
研究点 (1)
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