Effectiveness of Ultrasound-guided Alveolar Recruitment in Thoracic Surgery With One-lung Ventilation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 166
- 试验地点
- 2
- 主要终点
- P/F ratio
研究概览
简要总结
To observe the effectiveness of ultrasound-guided alveolar recruitment in thoracic surgery with one-lung ventilation(OLV).
详细描述
One-lung ventilation(OLV) is essential in thoracic surgery for patient safety and better surgical view. However, pulmonary complications such as hypoxemia may be caused by OLV which might be preventable with adequate alveolar recruitment and positive end-expiratory pressure(PEEP). Alveolar recruitment has been performed with conventional methods without diagnostic tools in clinical setting.
Ultrasound is a non-invasive, radiation-free device with high accuracy for the diagnosis of lung atelectasis. There are a few reports regarding the usefulness of lung ultrasound in other surgeries, but not in thoracic surgeries with OLV.
Thus, investigators designed a study to observe the effectiveness of ultrasound-guided alveolar recruitment in thoracic surgery with OLV.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position
排除标准
- •Patients who refuse to agree
- •Previous lung surgical history
- •History of pneumothorax or bullae
- •Severe cardiopulmonary disease, COPD
- •Operation time < 1hr
结局指标
主要结局
P/F ratio
时间窗: 30 minutes after one-lung ventilation
PaO2/FiO2 ratio
Incidence of desaturation
时间窗: intraoperative
SpO2\<95%
次要结局
- Lung ultrasound score(just after anesthesia induction, end of surgery)
- Alveolar dead space(30 minutes after one-lung ventilation)
- Pulmonary complications(intraoperative, during hospital stay(an average of 3 days))
研究者
Jeong-Hwa Seo
Professor
Seoul National University Hospital