Brain Diseases on 7.0T Magnetic Resonance Imaging
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- The visibility of white matter tracts on 7T MRI
研究概览
简要总结
This clinical trial studies the use of 7-Tesla (7T)and 3T magnetic resonance imaging (MRI) in detecting brain diseases. 7T MRI has increased detection sensitivity, including more accurate lesion delineation, higher inter-rater agreement. Diagnostic procedures such as 7T MRI may help ultimately improved diagnostic and therapies confidence to inform decision making than standard 3T MRI.
详细描述
7T MRI increased detection sensitivity, attain superior anatomic resolution, higher spatial and spectral specificity of advanced quantitative techniques, and shorter scan times than 3T MRI. When applied clinically, these benefits translate to increased detection sensitivity, and ultimately improved diagnostic and therapies confidence to inform decision making. This study aim to detect the image characteristics and diagnostic accuracy of brain diseases on 7T MRI.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age≥18 and ≤80
- •Having brain diseases (eg: brain tumor, cerebrovascular diseases)
- •Having no contraindications against MRI or intravenous contrast agent administration
- •Clinically stable
排除标准
- •Age<18 or >80
- •Pregnancy and other contraindication to MRI scan
- •Informed consent not obtained
结局指标
主要结局
The visibility of white matter tracts on 7T MRI
时间窗: within a month after biopsy
Visualization of white matter tracts will be done with the use of diffusion tensor imaging (DTI) on 7T MRI and measuring the mean diffusivity (MD) value on Post-processing workstation ,and analysis the correlation between these values and pathological.
the correspondence between brain tumor cells found in the biopsies and region of interest(ROI) signal intension on the 7T MRI scan and 3T MRI scan
时间窗: within a month after biopsy
Pathological assessment of biopsy material compared with the lesion's contrast-enhancement signal intension to normal brain white mater on 7T MRI and 3T MRI
次要结局
- The correlation between the ROI's signal intension on 7T MRI scan and the KPS in 1 month after operation(within a month after biopsy)
- The visibility of white matter tracts on 7T MRI and 3T MRI(Six months after the biopsy)
研究者
Xin Lou
Director and Clinical Professor
Chinese PLA General Hospital