Observational - Methylation Status as Predictor of Response to Neoadjuvant Chemotherapy in Osteosarcoma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Methylated status as predictor of response to neoadjuvant chemotherapy
研究概览
简要总结
This research study is studying biomarkers in predicting response to chemotherapy in samples from young patients with osteosarcoma. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients will respond to treatment.
详细描述
Study Subtype: Ancillary/Correlative Observational Study Model: Cohort Time Perspective: Retrospective Biospecimen Retention: Samples With DNA Biospecimen Description: Tissue Study Population Description: Children's Oncology Group Sampling Method: Non-Probability Sample
PRIMARY OBJECTIVES:
I. Determine whether methylation status predicts response to neoadjuvant chemotherapy in samples from children and young adults with osteosarcoma.
OUTLINE: Patients are stratified according to response to neoadjuvant chemotherapy (good vs poor).
DNA and RNA extracted from biopsy samples are analyzed for methylation changes and transcription changes by ligation-mediated PCR and mass-array genotyping.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 10 Years 至 20 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with high-grade osteoblastic osteosarcoma
- •Biopsy samples from patients who had good or poor response to neoadjuvant chemotherapy available
- •All specimens should be from post-menarchal females or age-matched males with appendicular tumors
- •Patients' clinical data including chemotherapy received, event-free survival, and overall survival available
- •See Disease Characteristics
排除标准
- 未提供
结局指标
主要结局
Methylated status as predictor of response to neoadjuvant chemotherapy
时间窗: Baseline
Performed on a locus-by-locus basis using Poisson regression (for count data) and/or two-group t-tests, with correction (Satterwaithe's) for unequal within-group variances.
次要结局
未报告次要终点