A Comparison of Functional Magnetic Resonance Imaging (fMRI) Findings in Children With and Without a History of Early Exposure to General Anesthetics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Use of fMRI as a tool
研究概览
简要总结
General anesthetic medications have been shown to cause neuronal cell death in the brains of infant rodents. Ethanol and general anesthetics both act on NMDA and GABA receptors,and appear to have similar mechanisms of toxicity in the immature rodent brain. Functional MRI (fMRI) is a technique developed for mapping brain activation and has been utilized to examine how the brains of children with a history of early exposure to ethanol function differently from children without such a history. This study will utilize fMRI to look for specific changes in brain activation patterns in children with a history of early exposure to general anesthesia, as compared to children without such exposure.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 10 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children ages 10-17 years with an history of exposure to general anesthesia for at least one hour in duration during the ages of 0-24 months of age.
- •The cognitive ability to complete fMRI imaging.
- •Consent of the subject's guardians and assent of the subject.
- •Right hand dominance.
- •English language speaker.
排除标准
- •Subjects with known possibility or knowledge of pregnancy.
- •Documentation of hemodynamic or respiratory instability documented on the anesthetic record
- •Subjects with the inability to complete MRI imaging without sedation.
- •History of prenatal ethanol exposure.
- •History of exposure to antiepileptic medication.
- •History of Attention Deficit Disorder (ADD), or Attention Deficit Hyperactivity Disorder (ADHD)
- •History of traumatic brain injury
- •History of psychiatric disease or exposure to psychoactive medications.
- •History of substance abuse.
结局指标
主要结局
Use of fMRI as a tool
时间窗: one time 10 to 17 yrs. post-anesthesia
To evaluate the use of fMRI as a tool to investigate the functional consequence of exposure to general anesthetic medications during early brain development
次要结局
- Brain activation patterns(one time 10 to 17 yrs. post-anesthesia)
研究者
Thomas Taghon
Attending Anesthesiologist
Nationwide Children's Hospital