Comparison of Umbilical Cord Blood Levels of Endocan in Pregnant Females With and Without Intrauterine Growth Retardation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- endocan in umbilical cord blood
研究概览
简要总结
As a proteoglycan secreted from endothelial cells, expression, and secretion of endocan increases in the endothelium of several tissues secondary to inflammation. It can be regarded as an indicator of endothelial damage. Besides, it is both a target and a modulator of the vascular endothelial growth factor (VEGF) signaling pathway. Considering its action mechanisms, it can provide information about angiogenesis, inflammation, and vascular permeability.
It is known that intrauterine growth retardation mainly occurs as a result of endothelial dysfunction and abnormal angiogenesis in the placenta. In previous studies, maternal serum endocan levels have also been shown to be increased in cases of preeclampsia, which is mainly characterized by placental dysfunction.So, we hypothesize that there may be an association between endocan levels and intrauterine growth retardation.
详细描述
Endocan is a proteoglycan that is closely associated with inflammation. Its levels increase in association with the severity of endothelial damage. Endothelial dysfunction and abnormal angiogenesis in the placental tissues are the main pathophysiological mechanisms leading to intrauterine growth retardation.
It has been known that there was a significant association between maternal serum levels of endocan and preeclampsia. In cases with preeclampsia, increased serum levels of endocan in maternal blood samples has been reported.
Intrauterine growth retardation is a situation in which endothelial dysfunction and abnormal angiogenesis are the leading disturbances. In fetuses with intrauterine growth retardation, a hypoxic environment secondary to uteroplacental insufficiency. In previous studies, increased levels of endocan in maternal blood samples have been shown. Although maternal blood can be a good reflector of situations both in fetuses and their mothers, measurement of endocan in umbilical cord blood samples may better represent the pathology in fetuses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •For "intrauterine growth retardation" group:
- •consent to participate study
- •detection of intrauterine growth retardation during follow up of pregnancy
- •For "healthy fetuses" group:
- •consent to participate study
- •absence of intrauterine growth retardation during follow up of pregnancy
排除标准
- •multiple pregnancy
- •presence of major developmental anomalies of fetuses
- •detection of chromosomal anomalies
- •malnourished mothers
- •vegetarian diet of mothers
- •use of cigarette and alcohol during pregnancy
- •previous history of stillbirths
结局指标
主要结局
endocan in umbilical cord blood
时间窗: just after delivery of fetus at clamping of umbilical cord
levels of endothelial cell specific molecule 1 (ng/ml) in umbilical cord blood
次要结局
未报告次要终点
研究者
cagdas özgökce
MD, specialist on obstetrics and gynecology
Van Bölge Eğitim ve Araştırma Hastanesi