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临床试验/NCT05188755
NCT05188755已完成不适用

Fitness Assessment in Young Adults Recovered From Lymphoma or Hodgkin's Disease

University Hospital, Clermont-Ferrand2 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2022年1月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
44
试验地点
2
主要终点
fat oxidation rate

研究概览

简要总结

Regular physical activity (PA) is associated with maintaining body composition, increased cardiorespiratory capacity, muscle mass and bone mineral density. In the event of a cancer, the development of physical capacities and metabolism may therefore be disturbed by cancer, these associated treatments (chemotherapy, radiotherapy and hematopoietic stem cell transplantation) but also undernutrition and the reduction in physical activity or even a sedentary lifestyle.

Although the benefits of PA in oncology are now well identified for adult populations, studies are still rare in the population of children, adolescents and young adults, and the results are still difficult to generalize. As a result, there is no recommendation on the practice of physical activity in pediatric oncology or adolescents and young adults and the levels of physical activity of cured patients remain lower than those of the general population.

Fitness is a marker of health in adults as well as in adolescents. Physical condition is a set of components such as cardiorespiratory capacity (transport and use of O2), body composition (distribution of bone, muscle and fat masses) and muscle function (strength, power, fatigue, energy metabolism) .

The investigators hypothesize that, compared to young adults, recovered from lymphoma are expected to exhibit impaired physical condition, due to physical deconditioning.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Diagnostic
盲法
None

入排标准

年龄范围
18 Years 至 25 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Young adult male or female, aged 18 to 25
  • giving free and informed consent
  • Hodgkin lymphoma or non-Hodgkin lymphoma in the healing stage
  • Cured (defined by an undetectable disease at the end of treatment) for at least one year and maximum 6 years of lymphoma or Hodgkin's disease

排除标准

  • Legal incapable adults
  • People under judicial protection
  • Treatment with systemic glucocorticoids for more than a week, during the 30 days preceding the tests
  • Medical contraindication to the practice of physical exercise
  • Any pathologies (other than the history of lymphoma for the cases) likely to affect the metabolism or the muscle mass
  • Any treatment that may have an influence on the energy metabolism
  • Active infection
  • Pregnant, breastfeeding, or likely to be
  • Subject's refusal to participate

结局指标

主要结局

fat oxidation rate

时间窗: day at 11:30 am during one day

maximum rate of lipid oxidation (in mg/ml)

次要结局

  • physical capacity(at 08:45 am during one day)
  • sedentary level(from day 2 to day 5)
  • blood N-terminal pro-B natriuretic peptide(at 07:30 am in fasted condition during one day)
  • Body composition: fat(at 07:30 am during one day)
  • blood insulinemia(at 07:30 am in fasted condition during one day)
  • physical activity level(from day 2 to day 5)
  • rest metabolism(at 08:00 am in fasted condition during one day)
  • blood troponin(at 07:30 am in fasted condition during one day)
  • blood lipids(at 07:30 am in fasted condition during one day)
  • blood glucose(at 07:30 am in fasted condition during one day)
  • Body composition: lean mass(at 07:30 am during one day)
  • cardiac output(at 11:30 am during one day)
  • peripheral quantitative computed tomography(at 10:45 am during one day)
  • physical condition(at 08:45 am during one day)

研究者

发起方
University Hospital, Clermont-Ferrand
申办方类型
Other
责任方
Sponsor

研究点 (2)

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