Nevoid Basal Cell Carcinomas in Young People With Gorlin Syndrome
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Nevoid basal cell carcinoma size increase
研究概览
简要总结
The overall aim of the project is to gain knowledge about the expected course of nevoid basal cell carcinomas and the usefulness of dermatoscopy in young individuals with Gorlin syndrome.
Clinical experience and some case-reports suggest that nevoid basal cell carcinomas have an indolent course with slow growth and that they can sometimes regress. However, no systematic research has previously been performed.
Increased knowledge about nevoid basal cell carcinomas and the use of dermatoscopy could be of great clinical value in the follow-up and treatment of individuals with nevoid basal cell carcinoma syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 17 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The individual has Gorlin syndrome (clinically and/or genetically diagnosed)
- •The individual is minimum 6 years and maximum 17 years
- •The individual has at least three skin lesions clinically compatible with nevoid basal cell carcinomas
排除标准
- •The patient has a psychiatric disorder not compatible with completion of the study examinations
- •The patient has received topical treatment (imiquimod, 5-fluorouracil, photodynamic therapy and/or cryotherapy) of nevoid basal cell carcinomas during the last three months
结局指标
主要结局
Nevoid basal cell carcinoma size increase
时间窗: Two years
Largest diameter (measured in millimeter) of nevoid basal cell carcinomas after two years surveillance compared to at baseline.
Dermatoscopy findings
时间窗: Two years
Dermatoscopy findings of nevoid basal cell carcinomas compared to nevoid basal cell carcinoma size increase.
次要结局
- Nevoid basal cell carcinoma histology(Two years)
研究者
Kristin Halvorsen Hortemo
Associate Professor, Medical Doctor
Oslo University Hospital