iver transplantation in patients with CirrHosis and severe Acute-on-Chronic Liver Failure (ACLF): iNdications and outComEs (CHANCE) Study on behalf of the EASL-CLIF Consortium - CHANCE

European Foundation for the Study of Chronic Liver Failure0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年1月9日

试验速览

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•1. Subjects with the diagnosis of liver cirrhosis
•2. subjects who have been hospitalized for acute decomposition of liver cirrhosis and referred to the transplant team
•3. Patients who have been informed and signed for informed consent

•1. Acute or subacute liver failure without underlying cirrhosis
•2. Patients with hepatocellular carcinoma outside Milan criteria or other active neoplasia
•3. Subjects listed for transplantation other than the liver or liver-kidney transplant
•4. Subjects with previous liver transplantation
•5. Vulnerable population
•6. Pregnant and/ or breastfeeding women
•Patients who cannot provide prior informed consent
•7. Patients and team not committed to providing intensive care if needed
•8. Patients with relevant comorbidities that could impact the prognosis:
•Subjects with very severe hepatopulmonary syndrome
•subjects with severe pulmonary disease obstructive lung disease
•subjects with chronic kidney disease requiring hemodialysis
•subjects with severe heart disease
•subjects with known infection with HIV
•subjects with neurological or psychiatric disorders

发起方

European Foundation for the Study of Chronic Liver Failure