Assessment of Emotional Memory During Transient Global Amnesia
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 2
- 试验地点
- 1
- 主要终点
- Ability to judge the degree of activation and emotional value associated with images
研究概览
简要总结
There are few studies on the role played by emotions in transient global amnesia (TGA), in particular with regard to their impact on the functioning of memory. The study investigators wish to better understand the link between episodic memory, emotional state and psychogenic factors during TGA. It would be interesting to see if the patients suffering from TGA triggered by a psychological shock process emotional information differently from those whose TGA was triggered by an "organic" shock (physical effort, trauma, etc.). Finally, amnesic stroke is a good model for better understanding the function of the hippocampus, in particular of the CA1 region, in episodic memory.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subject with no history of transient global amnesia or neurological or psychiatric pathology.
- •Patients with a transient global amnesia according to the criteria of Hodges and Warlow (1990) in the acute phase (i.e. within 24 hours after the onset of the stroke), accompanied by a trusted person
- •The patient must have given their free and informed consent and signed the consent form
- •The patient must be a member or beneficiary of a health insurance plan
排除标准
- •The subject is participating in another study, or is in a period of exclusion determined by a previous study
- •The subject refuses to sign the consent
- •It is impossible to give the subject informed information
- •The patient is under safeguard of justice or state guardianship
- •The patient is pregnant or breastfeeding
- •Presence of a focal neurological pathology that may explain the symptoms, history of epilepsy or psychiatric disorders.
- •Hypersensitivity to iodinated contrast media.
- •Known allergy to 18-FDG.
- •Non-inclusion criteria concerning control subjects:
- •Presence of disorders on neurological assessment
- •Presence of cognitive disorders on the neuropsychological assessment (z-score <-1.65 on the RBANS or on the Stroop test).
- •Exclusion criteria for the target population:
- •Patients will be excluded after the 1st neuropsychological assessment if episodic memory tests show complete recovery from anterograde amnesia.
结局指标
主要结局
Ability to judge the degree of activation and emotional value associated with images
时间窗: Day 0
Self Assessment Manikin (SAM)
Storage and retrieval capacities of information with a strong emotional valence in patients compared to healthy controls
时间窗: Day 0
International Affective Picture System (IAPS): number of correctly memorized images of each type of emotional content (15 positive, 15 negative and 15 neutral).
次要结局
- Anxiety(Day 0)
- Depression(Day 0)
- Repeatable Battery for the Assessment of Neuropsychological Status between patients and healthy control(Day 0)
- Change in storage and retrieval capacities of information with a strong emotional valence in patients from baseline(Month 3)
- Mood(Day 0)
- Identification of hypometablic zones by PET compared to age- and sex-matched controls(Day 0)
- Classification of event triggering transient global amnesia(Day 0)
- C-score of the Groupe de REflexion pour l'Evaluation des Fonctions Exécutives (GREFEX) version of Stroop Test between patients and healthy control(Day 0)