Diagnostic Value and Biological Significant of cd71 in Lymphoid Dis Order
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 139
- 主要终点
- determin diagnostic value of cd71 in lymphoid disorder
研究概览
简要总结
CD71 is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues. , reflecting the requirement for iron in hemoglobin. , CD71 expression is upregulated on immature proliferating cells and low levels on resting mature lymphocytes. In addition to this general function, CD71 appears to play a costimulatory role in T cell activation and receptor for IgA1 antibodies So it is growth receptor that may help in diagnosis of lymphoid disorder and in differentiation of malignant and benign that will be studied investigate CD71 expression in lymphoid disorders and its diagnostic value ,we from collect data patient and do rotune examination
详细描述
- Routine investigations for diagnosis:
- CBC.
- Bone marrow aspiration morphology.
- Cytochemistry.
- Flow cytometry immunophenotyping.
- Bone marrow biopsy when indicated.
- Special investigation is flow cytometry examination of CD71 expression.
sample size calculation ; sample size cases 39 sample size controls 39 total sample size 79 sample will be collected from patient in hospital university ,Data will be analysed by SPSS program
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients wiil be diagnosed lymphoid disorders
排除标准
- •not present
结局指标
主要结局
determin diagnostic value of cd71 in lymphoid disorder
时间窗: baseline
Routine investigations for diagnosis: CBC. Bone marrow aspiration morphology. Cytochemistry. Flow cytometry immunophenotyping. Bone marrow biopsy when indicated. Special investigation is flow cytometry examination of CD71 expression. total sample size 79 person .sample will be collected from patient in hospital university ,Data will be analysed by SPSS program it is growth receptor is expressed on activated B and T cells, macrophages, reticulocytes, erythroid precursors, and malignant tissues
次要结局
未报告次要终点
研究者
Marwa Aboelim Shafeik
Principal investigator
Assiut University