Short Term Effects of Propanolol on Heart Rate Variability of Hyperthyroidism
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 主要终点
- Heart rate variability
研究概览
简要总结
Objective: The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.
Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).
Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours.
详细描述
Objective
The aim of our study was to evaluate the short term effects of Propanolol on heart rate variability in patients with hyperthyroidism.
Design: In ten patients newly diagnosed as having hyperthyroidism and naïve of all treatment specific for hyperthyroidism, we evaluated the short term effects of Propanolol on heart rate variability (HRV).
Methods: We measured heart rate variability by power spectral analysis during 2 hours of rest and during Ewing's tests before and after the administration of Propanolol 40mg/12 hours orally for 72 hours. Other outcomes included mean heart rate, mean R-R interval during 2-hour rest.
The study questions the systematic adjunction of Propanolol early in the treatment of hyperthyroidism.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •consenting patients referred to or diagnosed at the National Centre of Obesity of the Yaounde Central Hospital as having hyperthyroidism
- •naïve of all treatment specific for hyperthyroidism.
- •aged 18-70 years
排除标准
- •Patients already under a specific treatment for hyperthyroidism
- •Patients taking beta blockers or any other cardiospecific treatment
- •Patients presenting complications including acute thyrotoxic crisis, or symptomatic cardiac failure
- •Contraindications to the prescription of beta blockers
研究组 & 干预措施
Intervention
72-hour propanolol before specific treatment of hyperthyroidism
干预措施: Propanolol (Drug)
结局指标
主要结局
Heart rate variability
时间窗: 72 hours
Sympatho vagal tone measures
次要结局
- Heart rate(72 hours)
研究者
Sobngwi Eugene
Professor of Endocrinology and Metabolism
Yaounde Central Hospital