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临床试验/NCT04651049
NCT04651049已完成不适用

Influence of Systemic Propranolol Treatment on the Physical Development of Paediatric Patients With Infantile Hemangiomas

Qilu Hospital of Shandong University0 个研究点目标入组 128 人开始时间: 2010年7月15日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
已完成
入组人数
128
主要终点
Change on the height of the patients

研究概览

简要总结

This is retrospective study. The patients treated with oral propranolol at a dose of 2.0 mg/kg per day. Growth parameters (height and weight) were measured at the beginning, the end of treatment and 2 years after treatment. The weight-for-age Z-score (WAZ), height-for-age Z-score (HAZ) and weight-for-height Z-score (WHZ) calculated by the WHO Anthro software were used to assess physical development, and the WHO Child Growth Standards were used as the standards.

研究设计

研究类型
Observational
观察模型
Case Crossover
时间视角
Retrospective

入排标准

年龄范围
2 Weeks 至 54 Weeks(Child)
性别
All
接受健康志愿者

入选标准

  • IHs diagnosed by medical history and physical examination
  • no previous treatment with other medications

排除标准

  • a history or risk of asthma, reactive airway disease, impaired renal or liver function, heart defects or arrhythmia, hypotension and hypersensitivity to propranolol
  • Infants who did not adhere to the treatments or attend follow-up visits
  • Infants with other known risk factors for developmental delay or growth restriction, such as prematurity, small for gestational age, or other major congenital malformations, were also excluded
  • No other treatment was used during the oral propranolol course

研究组 & 干预措施

Propranolol treatment group

干预措施: propranolol (Drug)

结局指标

主要结局

Change on the height of the patients

时间窗: at the beginning of the treatment, at the end of treatment and 2 years after the treatment

we recorded the height of the patients in meters.

Change on the weight of the patients

时间窗: at the beginning of the treatment, at the end of treatment and 2 years after the treatment

we recorded the weight of the patients in kilograms.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

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