NCT02146963已完成不适用
Study of the BDNF- Val66Met Polymorphism in Alcohol-dependent Subjects in Relation to Abstinence After Withdrawal
Centre Hospitalier Esquirol1 个研究点 分布在 1 个国家目标入组 180 人开始时间: 2014年5月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Frequency of the Bdnf gene Val/Val, Val/Met and Met/Met phenotypes as a function of relapse
研究概览
简要总结
This study is complementary to the main study "Brain Derived Neurotrophic Factor Serum Levels Evolution During the Six Months After Alcohol Withdrawal " NCT01491347.
The purpose of this study is to evaluate the Bdnf gene - Val66Met polymorphism in subjects with alcohol dependence according to their alcohol consumption status 6 months after withdrawal (relapse or abstinence), in relation to the presence of psychiatric co-morbidities.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •participation to the study "BDNF serum levels evolution during 6 months after alcohol withdrawal" (main study)
- •criteria from the main study
排除标准
- •criteria from the main study
- •released or out from the main study before the follow-up at 4 months after withdrawal
结局指标
主要结局
Frequency of the Bdnf gene Val/Val, Val/Met and Met/Met phenotypes as a function of relapse
时间窗: at the time of inclusion
次要结局
- serum BDNF levels variations between inclusion and 6 months later (or 4 months if the participants does not come for the 4 months-follow-up).(6 months after alcohol withdrawal)
- presence of a psychiatric co-morbidity at 6 months after withdrawal (major depression, schizophrenia, anxiety disorder)(6 month after alcohol withdrawal)
- existence of a psychiatric co-morbidity at the inclusion (major depression, schizophrenia, anxiety disorder)(at the time of inclusion)
研究者
Philippe Nubukpo
MD, PhD
Centre Hospitalier Esquirol
研究点 (1)
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