Prevalence of of Apical Periodontal in Patients Chronic Kidney Disease & Its Association With Markers of Kidney Disease.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 210
- 试验地点
- 1
- 主要终点
- serum creatinine
研究概览
简要总结
This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy individuals.
详细描述
105 CKD patients (35 early (EG), 35pre-dialysis (PDG) and 35 hemodialysis (HDG)groups and 105 age and gender matched healthy controls were assessed for prevalence and severity of apical periodontitis and oral disease burden . Inflammatory (hsCRP and ferritin) and nutritional (urea and creatinine) markers were estimated and eGFR was calculated for the study population. Logistic regression was used to determine the possible association between CKD and AP in study population and Linear regression was performed to evaluate the possible association between systemic markers and endodontic burden (EB) in experimental group.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Known patient of CKD Stages 1,2,3,4 & 5 with estimated glomerular filtration rate [eGFR; MDRD] with mature permanent teeth.
- •> 18 years
- •> 8 natural teeth.
- •Complete medical & dental history including panoramic radiographs of maxilla & mandible
排除标准
- •Patients having systemic disorders other than CKD (eg HIV, Diabetes mellitus, Coronary heart disease, history of secondary hyperparathyroidism).
- •Pregnancy, lactation & contraceptives.
- •Systemic conditions that contra indicates dental treatment.
- •Use of antibiotics & anti-inflammatory in last 3 months
- •Need for antibiotic prophylaxis.
- •Hepatitis C and B virus.
- •Patients on steroids.
结局指标
主要结局
serum creatinine
时间窗: 1 year
BY BLOOD SAMPLE measured in mg/dL
Blood urea
时间窗: 1 year
measured by collecting blood sample in mg/dL
Periapical Index(PAI)
时间窗: 1 year
Periodical status will be assessed in periodical radiograph and scoring of periapical index will be done according to size and periphery of peri-apical radiolucency with coding 1 to 5
eGFR
时间窗: 1 year
BY BLOOD SAMPLE measured in mL/min/1.73m2
hs-CRP
时间窗: 1 year
HIGH SENSITIVE C-reactive protein measured by ELISA kit in mg/L
次要结局
未报告次要终点