Risk Factors of Sternal Wound Infection After Coronary Artery Bypass Graft
试验速览
- 阶段
- 不适用
- 入组人数
- 1,850
- 试验地点
- 1
- 主要终点
- postoperative surgical wound infection
研究概览
简要总结
The investigators are trying to evaluate the performance of neutrophil and lymphocyte counts as a risk factor of deep sternal wound infection after coronary artery bypass graft surgery.
详细描述
Deep sternal wound infection after coronary artery bypass graft is a very dangerous complication as it prolongs hospital stay, increase morbidity and mortality, and increase cost of care.
As a risk factor of surgical site infection, risk index reported by NNIS (national nosocomial infection surveillance), Euroscore, or Society of thoracic surgeon risk score are currently used. However, as various performances are reported regarding these index or scoring systems, and many factors are needed for these index or scoring system, there is a need to develop a more simple risk factor with better performance. We focused on the differential blood cell count, as the neutrophil and lymphocyte count are related to the degree of surgical invasion, and inflammatory response. Previous studies reported that the neutrophilia or lymphopenia is related to postoperative infection. Therefore, we are trying to evaluate the performance of preoperative or postoperative the blood cell differential count as a risk factor for sternal wound infection after coronary artery bypass surgery.
研究设计
- 研究类型
- Observational
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 90 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Those underwent coronary artery bypass graft surgery with median sternotomy in Samsung Medical Center during the period of January 2008 and December 2011.
排除标准
- •Those underwent coronary artery bypass graft surgery with mini-thoracotomy
- •Those with insufficient study data recognized by electronic medical record
结局指标
主要结局
postoperative surgical wound infection
时间窗: within first week after the end of coronary artery bypass graft surgery
postoperative surgical wound infection within first week after the end of coronary artery bypass graft surgery, classified as a superfical or deep sternal wound infection
次要结局
- preoperative total leukocyte count(1 day before surgery)
- preoperative neutrophil count(1 day before surgery)
- preoperative EuroScore(1 day before surgery)
- postoperative lymphocyte count(2 hour after the end of surgery)
- preoperative NNIS risk index(1 day before surgery)
- preoperative lymphocyte count(1 day before surgery)
- postoperative neutrophil count(2 hour after the end of surgery)
- Preoperative STS(1 day before surgery)
- postoperative total leukocyte count(2 hour after the end of surgery)
- the incidence of surgical reopen with surgical wound infection(within 1 month after surgery)
研究者
Sangmin M. Lee
Professor
Samsung Medical Center
