Effectiveness of Preoxygenation With Positive Airway Pressure in Non-obese Healthy Patient: a Comparison of the Supine and 25° Head up Position
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- non-hypoxic apnoeic period (time to fall SpO2 to 92%)
研究概览
简要总结
Several techniques such as positive airway pressure and head-up tilt during preoxygenation have shown to prolong non-hypoxic apnea period compared to conventional technique. However, uniform recommendations have not yet been made. Therefore, in the present study the investigators attempted to find out the effect of combination of 5 cmH2O CPAP and 25° head up position during preoxygenation.
详细描述
In this study 60 non-obese healthy adult patients were divided into three groups; Group C receiving preoxygenation in conventional technique, Group S receiving preoxygenation with 5 cmH2O CPAP and Group H receiving preoxygenation in 25° head-up position with 5 cmH2O CPAP. After 3 min of preoxygenation, anesthesia was induced and trachea intubated. After confirming the tracheal intubation by direct visualization, all patients were left apneic in supine position with the tracheal tube exposed to atmosphere till the SpO2 dropped to 92%. The primary outcome compared between the groups was the non-hypoxic apnoeic period (time to fall SpO2 to 92%).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •adult patients of ASA physical status I and II undergoing surgery under general anaesthesia
排除标准
- •anticipated difficult mask ventilation/ intubation
- •individuals with significant cardiorespiratory or cerebrovascular disease
- •pregnant ladies
- •patient with history of epilepsy
- •body mass index >25 kg/m2
- •hemoglobin <8 gm/dL
- •patients who were non-ambulant for >24 h, having SpO2 < 97% while breathing in room air
- •phobia to facemask.
研究组 & 干预措施
Conventional
preoxygenation done with 100% oxygen in supine position
Positive-pressure
preoxygenation done with 5 cmH2O CPAP (continuous positive airway pressure) in supine position with 100% oxygen
干预措施: 5 cmH2O CPAP (Other)
Head-up
preoxygenation done in 25 degree head-up position with 5 cmH2O CPAP with 100% oxygen
干预措施: 5 cmH2O CPAP (Other)
Head-up
preoxygenation done in 25 degree head-up position with 5 cmH2O CPAP with 100% oxygen
干预措施: head-up position (Other)
结局指标
主要结局
non-hypoxic apnoeic period (time to fall SpO2 to 92%)
时间窗: 2 hours
After 3 min of preoxygenation, anesthesia was induced and trachea intubated. After confirming the tracheal intubation by direct visualization, all patients were left apneic in supine position with the tracheal tube exposed to atmosphere till the SpO2 dropped to 92%.
次要结局
- Comparison of PaCO2 at different time points(2 hours)
- Comparison of pH at different time points(2 hours)
- Comparison of PaO2 at different time points(2 hours)
研究者
Yogesh Dhakal
Assistant Professor, Department of Anaesthesiology and Critical Care
B.P. Koirala Institute of Health Sciences