MR Radiomic Features in Prostate Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Number of surrogate bioimaging markers of histological characteristics in MR images
研究概览
简要总结
A combination of correct interpretation of imaging and biopsy has given promising results in terms of detecting clinically significant cancer at radical prostatectomy.
详细描述
Quantitative approaches to medical image analysis have been developed in recent years with the aim to overcome the limitation of qualitative image interpretation, and provide biomarkers for disease characterization. In particular, the new paradigm, "radiomics", is emerging as the high-throughput extraction of quantitative features from imaging which can aid in characterizing phenotype as in vivo expression of tumoral genotype. The goal of radiomics is to extract accurate and reliable quantitative biomarkers which enhance diagnostic confidence in oncology. A combination of correct interpretation of imaging and biopsy has given promising results in terms of detecting clinically significant cancer at radical prostatectomy.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •> 18 years of age
- •In house MRI with contrast medium
- •PCa (prostate cancer) biopsy proven diagnosis
- •In house radical prostatectomy
排除标准
- •< 18 years of age
- •MRI without contrast medium
- •Radical prostatectomy executed not in Institution
结局指标
主要结局
Number of surrogate bioimaging markers of histological characteristics in MR images
时间窗: 0-2 years
Segment tumor volumes on the ADC map and extract different imaging features
次要结局
- Radiomic features from MRI(0-2 years)
- Extract radiomic features(0-2 years)
研究者
Francesco De Cobelli
Head, Radiology Department
IRCCS San Raffaele