Effect of Watermelon and Beetroot Products on Endothelial Function in Young and Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Flow-mediated dilation (FMD)
研究概览
简要总结
Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases. Endothelial dysfunction occurs due to reduction in nitric oxide, a molecule that plays an important role on vascular health. Due to important role of nitric oxide in endothelial function, several studies have evaluated the effect of its precursors, such as L-citrulline and nitrate on endothelial function parameters. The present study will evaluate the effect of L-citrulline and nitrate derived by watermelon and beetroot products, respectively, on endothelial function of young and older participants. Furthermore, we will evaluate the plasmatic amino acids, nitrate, glucose and insulin in response to ingestion of these products.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for healthy young participants:
- •Age between 18-35 years;
- •Triglycerides ≤ 150 mg/dL
- •HDL-cholesterol ≥ 50 mg/dL for women and ≥ 40 mg/dL for men;
- •Waist circumference ≤ 102 cm for men and ≤ 88 cm for women).
- •Inclusion Criteria for older people with cardiovascular risk:
- •Age ≥ 60 years;
- •Elevated triglycerides ≥150 mg/dL;
- •Reduced HDL-cholesterol ≤ 50 mg/dL for women and ≤ 40 mg/dL for men;
- •Elevated waist circumference ≥102 cm for men and ≥ 88 cm for women).
排除标准
- •Elevated fasting glucose (≥100 mg/dL);
- •Beetroot or watermelon allergy;
- •Unwillingness to avoid beetroot or watermelon products during the entire study;
- •Other chronic diseases (diabetes, liver disease, etc.) or acutely ill
研究组 & 干预措施
Beetroot
Beetroot powder containing 8 mmol of nitrate.
干预措施: Beetroot (Dietary Supplement)
Watermelon + beetroot
Watermelon powder containing 3 g of L-citrulline and Beetroot powder containing 8 mmol of nitrate.
干预措施: Watermelon + beetroot (Dietary Supplement)
Placebo
Maltodextrin
干预措施: Placebo (Dietary Supplement)
Watermelon
Watermelon powder containing 3 g of L-citrulline.
干预措施: Watermelon (Dietary Supplement)
结局指标
主要结局
Flow-mediated dilation (FMD)
时间窗: This measure will be evaluate 120 minutes after the nutritional intervention
Muscle oxygen saturation
时间窗: This measure will be evaluate 120 minutes after the nutritional intervention
Muscle oxygen saturation
时间窗: This measure will be evaluate 30 minutes after the nutritional intervention
Muscle oxygen saturation
时间窗: This measure will be evaluate 60 minutes after the nutritional intervention
Muscle oxygen saturation
时间窗: This measure will be evaluate 90 minutes after the nutritional intervention
Flow-mediated dilation (FMD)
时间窗: This measure will be evaluate 60 minutes after the nutritional intervention
Muscle oxygen saturation
时间窗: This measure will be evaluate before the nutritional intervention
Flow-mediated dilation (FMD)
时间窗: This measure will be evaluate before the nutritional intervention
次要结局
- Plasmatic amino acids(This measure will be evaluate 120 minutes after the nutritional intervention)
- Plasmatic insulin(This measure will be evaluate 120 min after the nutritional intervention)
- Plasmatic glucose(This measure will be evaluate 120 min after the nutritional intervention)
- Plasmatic amino acids(This measure will be evaluate before the nutritional intervention)
- Plasmatic amino acids(This measure will be evaluate 30 minutes after the nutritional intervention)
- Plasmatic amino acids(This measure will be evaluate 60 minutes after the nutritional intervention)
- Plasmatic amino acids(This measure will be evaluate 90 minutes after the nutritional intervention)
- Plasmatic glucose(This measure will be evaluate before the nutritional intervention)
- Plasmatic glucose(This measure will be evaluate 30 min after the nutritional intervention)
- Plasmatic glucose(This measure will be evaluate 60 min after the nutritional intervention)
- Plasmatic glucose(This measure will be evaluate 90 min after the nutritional intervention)
- Plasmatic insulin(This measure will be evaluate before the nutritional intervention)
- Plasmatic insulin(This measure will be evaluate 30 min after the nutritional intervention)
- Plasmatic insulin(This measure will be evaluate 60 min after the nutritional intervention)
- Plasmatic insulin(This measure will be evaluate 90 min after the nutritional intervention)
研究者
Thiago Alvares
Principal Investigator
Universidade Federal do Rio de Janeiro