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临床试验/NCT01967420
NCT01967420已完成不适用

Using Computerised Training to Improve Cognition and Functioning in the First Episode of Psychosis

University of Manchester1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2013年8月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
40
试验地点
1
主要终点
Emotion Recognition Task

研究概览

简要总结

This study aims to look at the effectiveness of a combination of cognitive remediation and social cognition training to improve cognition and functioning when compared to cognitive remediation alone. The target population will be those who are experiencing their first episode of psychosis.

详细描述

A first episode of psychosis is defined as the first experience of positive symptoms, such as hallucinations and delusions, and the behaviour that accompanies it. This is associated with problems in many areas of cognition; the ability to acquire knowledge and understanding. These cognitive symptoms have been found to have a large impact on daily functioning (e.g. accessing education or employment and maintaining relationships) and cannot effectively be treated with medication. Cognitive remediation (CR) is a therapy that aims to improve cognition and, through generalisation of this, improve daily functioning and quality of life. Although it is an area of deficit, social cognition, the ability to perceive and understand emotional states, is often not targeted in cognitive remediation. However, interventions which have focused on providing social cognition training (SCT) alongside CR have shown large improvements in daily functioning.

This study aims to look at the effectiveness of a combination of CR and SCT to improve cognition and functioning when compared to CR alone. The target population will be those who are experiencing their first episode of psychosis. Participants will be recruited from an Early Intervention in Psychosis service which is an NHS service set up to provide rapid treatment for those experiencing psychosis.

Participants will take part in a ten week CR or CR+SCT intervention which will consist of spending 90 minutes a week in a small group setting working through a series of computer games which aim to improve cognition. Interviews and questionnaires regarding daily functioning, cognition, quality of life and symptoms will be used before and after the intervention. Participants will be asked to attend follow-up interviews 6 months after the intervention has ended to complete the measures again to see if any beneficial effects have lasted.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Treatment
盲法
Single (Care Provider)

入排标准

年龄范围
18 Years 至 35 Years(Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Non-affective psychosis
  • •Premorbid IQ of over 70
  • •A service user of the early intervention service
  • •Aged 18 or over (up to the age of 35 which is the limit for the early intervention service)
  • •Psychiatrically stable enough to attend to completion (no hospitalisations or medication changes in last 4 weeks)

排除标准

  • •Active substance dependency
  • •History of severe head injury

研究组 & 干预措施

Cognitive remediation plus social cognition training

Experimental

A combined intervention of 60 minutes of computerised cognitive remediation and 30 minutes of computerised social cognition training.

干预措施: Cognitive remediation (Behavioral)

Cognitive remediation plus social cognition training

Experimental

A combined intervention of 60 minutes of computerised cognitive remediation and 30 minutes of computerised social cognition training.

干预措施: Social cognition training (Behavioral)

Cognitive remediation alone

Active Comparator

An active control condition consisting of 60 minutes of computerised cognitive remediation and 30 minutes of free computer time.

干预措施: Cognitive remediation (Behavioral)

结局指标

主要结局

Emotion Recognition Task

时间窗: 10 weeks

The emotion recognition task of the computerised Cambridge neuropsychological test automated battery (CANTAB).

次要结局

  • Personal and Social Performance Scale (PSP)(10 weeks and 6 month follow-up)
  • CANTAB schizophrenia battery(10 weeks and 6 month follow-up)
  • Specific levels of functioning scale (SLOF)(10 weeks and 6 month follow-up)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Emily Revell

Postgraduate Researcher

University of Manchester

研究点 (1)

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