Diagnostic Accuracy of Increased Serum Cytokine Levels as a Marker of Paralytic Ileus Following Robotic Radical Cystectomy
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Correlation between cytokine rise (intra-and post-operatively) and postoperative ileus following robotic radical cystectomy
研究概览
简要总结
There is a recognised complication of surgery known as a 'Paralytic Ileus', where bowel function is reduced after an operation, causing an obstruction and resulting in nausea and vomiting. This complication is more common in patients that have robotic surgery due to the positioning required and the gas pressures required for keyhole/robotic surgery. While some of the factors involved in a paralytic ileus are known, the full mechanism and the chemicals involved are not yet fully understood.
This study is looking at the level of specific chemicals called 'cytokines', and the changes in the level of these cytokines in the blood before and after robotic surgery, specifically during bladder removal (cystectomy). Cytokine levels will be compared against post-operative recovery and whether a paralytic ileus is developed.
详细描述
Cytokines are signalling proteins that are release by immune cells in response to stress on the body. In this study the aim is to evaluate the concordance between cytokine rise (specifically monitoring the following cytokines: Interferon (IFN)-gamma, tumour necrosis factor (TNF)-alpha, Interleukin (IL) -1beta, IL-2, IL-4, IL-6, IL-12 and IL-17) and postoperative ileus (a condition where bowel function slows causing build up of faecal matter) following robotic radical cystectomy and the pneumoperitoneum (gas insufflation of the abdomen) pressures that were required intra-operatively.
This study includes patients undergoing radical cystectomy. The study will measure pre-anaesthetic, post-anaesthetic, immediately post-operatively and two further post-operative serum cytokines levels and compare them with the pneumoperitoneal pressures required intra-operatively and the outcome of whether a clinical diagnosis of paralytic ileus was made.
Serum cytokine levels will be taken on five occasions:
- st Sample (Baseline)-Before induction of anaesthetic
- nd Sample-Immediately after induction of anaesthetic
- rd Sample-Immediately post-operative
- th Sample - 2 hours post-operative
- th Sample - 1 day post-operative
No alterations will be made to the care of the patient, this is purely an observational study.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients aged between 40 and 75 years of age
- •Patients undergoing a Robotic radical cystectomy
- •Patient consenting to enter the study
- •Patients consenting for blood samples for cytokine analysis
排除标准
- •Patients <40 years of age and patients >75 years of age
- •Patients unwilling or unable to consent
结局指标
主要结局
Correlation between cytokine rise (intra-and post-operatively) and postoperative ileus following robotic radical cystectomy
时间窗: 24 hours post-surgery
Serum cytokine levels
次要结局
未报告次要终点