ATP Level in Induced Sputum and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- ATP Level in Sputum Supernatant
研究概览
简要总结
This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained chronic cough and 30 matched healthy controls were recruited. Demographic data, clinical characteristic, cough sacles and medical history records were collected. Cough chanllage(ATP and capsaicin) and ATP measurement in sputum were conducted.The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
ATP Level in Sputum Supernatant
时间窗: ATP concentrations were measured in all specimens on the day of the last participant's enrollment.
ATP level in induced sputum in patients with refractory/unexplained chronic cough and healthy control
次要结局
- ATP Cough Sensitivity(Each subject underwent ATP cough challenge on the day of enrollment.)
研究者
Kefang Lai
Director of Clinical Research Department
The First Affiliated Hospital of Guangzhou Medical University