Multi-limb Control in Parkinson's Disease: Implicit and Explicit Control of Attention
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Dual Task Effect on Arm and Foot Tasks
研究概览
简要总结
People with Parkinson disease commonly experience difficulty driving, which requires the arms and legs to do different tasks simultaneously. Driving difficulties can lead to isolation, depression, loss of independence and mobility, and increased incidence of car accidents. Through understanding the impact of Parkinson disease on mechanisms underlying attention and multi-limb control, training and rehabilitation programs can better focus on the needs of drivers with Parkinson disease. The proposed study aims to address this need by taking measures of simulated driving at one point in time. Subjects with PD are tested at a single time point when they are at their "best" point in their day and on another day when they are at their worst and are about to take their next dose of medication. Healthy age-matched subjects are not taking anti-parkinson medication so are tested at only one point.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •have a clinical diagnosis of mild to moderate idiopathic PD (Hoehn & Yahr stages 1-3),
- •hold a valid driver's license and drive at least once a week, and
- •be capable of providing informed consent and complying with study procedures. Control group participants will be healthy, neurologically intact individuals, age-matched to within 2 years of the PD subjects.
排除标准
- •impaired global cognition (i.e., a score of < 20 on the Montreal Cognitive Assessment (MoCA) screening tool)
- •sensory loss in the lower limb as assessed by clinical test of vibration perception at the ankle,
- •orthopedic, visual, or neurological conditions that would prevent performance of the experimental tasks,
- •inability to complete and pass the assessment testing,
- •history of neurological illness such as head trauma, previous stroke, epilepsy, demyelinating disease, or
- •complicating medical problems such as diabetes.
结局指标
主要结局
Dual Task Effect on Arm and Foot Tasks
时间窗: Subjects with PD: Two 90-minute sessions within a week; Healthy controls: One 90-minute session, observation of simulated driving.
The Dual Task Effect is the performance measure of the arm and foot task, respectively, in the dual task relative to the single task, expressed as a percentage.
次要结局
未报告次要终点
研究者
Tara McIsaac
Professor
A.T. Still University of Health Sciences