The Effect of Psoriatic Arthritis on Female Sexual Dysfunction and Their Relation to Sex Hormones
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 180
- 试验地点
- 1
- 主要终点
- Evaluation of female sexual function
研究概览
简要总结
Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.
详细描述
Psoriasis is one of the most common immunemediated chronic inflammatory skin disorders.
Beside genetic factors, several environmental factors such as injuries, infections, stress, drugs, and immune defect take part in autoimmune pathogenesis of the disease. In addition, it has been reported that some hormones may also have a role in the pathogenesis of psoriasis, due to their effects on keratinocytes proliferation.
Studies revealed that sex hormones manifest a variety of biological and immunological effects in the skin which modulate the natural course of psoriasis.
Approximately 20-30% of patients with psoriasis may also have psoriatic arthritis, which often causes significant musculoskeletal pain that significantly impairs quality of life (QoL).
Although sexual dysfunction is a common complaint, affecting 30 to 70% of psoriasis patients, few studies have analyzed the impact of psoriasis and psoriatic arthritis on quality of sexual life.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •The study will focuses on the relationship between the FSD and PsA;
- •The healthy controls will derive from a population within the same geographic area and ethnic background as PsA;
- •Used the same questionnaires/instruments of FSFI to diagnose FSD
排除标准
- •pregnancy,
- •breastfeeding
- •being sexually inactive
- •having a partner with sexual dysfunction,
- •refusing to participate, or
- •being unable to read
- •Females with any sexual transmitted disease
结局指标
主要结局
Evaluation of female sexual function
时间窗: 6 months
To identify and understand the mechanisms of sexual problems in Psoriatic arthritis Patients in Qena university hospital.
次要结局
未报告次要终点