Investigation on the effectiveness of antenatal corticosteroid in late preterm twin pregnancy

Seoul National University Hospital0 个研究点目标入组 808 人开始时间: 待定最近更新: 2019年11月5日

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•1) Twin pregnancy
•2) Age?>?20?years
•3) Women with twin pregnancy at 34?weeks 0?days to 36?weeks 5?days of gestation
•4) At risk for preterm birth
•- preterm labor
•- PPROM (preterm premature rupture of membranes)
•** threatened preterm labor: regular uterine contraction with or without following symptoms
•- pelvic pressure, backache, increased vaginal discharge, menstrual-like cramps, bleeding/show, cervical chages

•1) Gestational age before 34?weeks 0?days or after 36?weeks 6?days
•2) Lethal major fotal anomaly, fetal distress or fetal death in utero, placenta abruption
•3) Expected to deliver within 12?h
•- Advanced cervical dilatation (=8?cm) in preterm labour
•- Active phase labour (cervical dilatation =4?cm) in PPROM
•4) History of a previous administration of antenatal corticosteroid within 1?week
•5) Administration of systemic steroid for medical indications
•6) Diagnosis of clinical chorioamnionitis : fever >37.8? and satisfy two of the followings
•- uterine tenderness
•- foul-odored vaginal discharge
•- maternal leukocytosis (>15,000)
•- maternal tachycardia (>100)
•- fetal tachycardia (>160)
•7) Contraindication of betamethasone administration
•- patients with hypersensitivity
•- infectious disease or systemic fungal infection patient without effective antibacterial/antifungal agent
•- patients with infections within the joint cavity, intramucosa, and tendon
•- patients with unstable joints (deterioration of joint symptoms)
•- patients with herpes simplex, herpes zoster, chickenpox
•- live vaccine administration patients

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