Association Between Prescription of Antidepressants and Delirium in the Elderly : Analysis From the World Health Organization Global Database
试验速览
- 阶段
- 不适用
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Descriptive analysis of the studied population
研究概览
简要总结
Delirium is a frequent reason for hospitalisation of the elderly. Associations between the prescription of some medicines and the risk of delirium have already been demonstrated.
Antidepressants are widely prescribed in the elderly because of the frequency of anxiety-depressive symptoms in this population, where there are high pharmacokinetic and pharmacodynamic variability.
However, the association between antidepressants and the risk of delirium remains poorly understood.
Based on the analysis from the World Health Organization global database, the main objective of this study is to investigate the association between the different classes of antidepressants and the occurrence of the " delirium " event reported in the database.
A disproportionality analysis will be performed. It will aim to assess whether some classes of antidepressants, and within these classes some molecules, are associated with a greater risk of delirium.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 120 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •be over 65 years old
- •taking antidepressants
- •to have presented delirium
排除标准
- 未提供
结局指标
主要结局
Descriptive analysis of the studied population
时间窗: 03/01/2022
From the WORLD HEALTH ORGANIZATION Vigibase pharmacovigilance database, the investigators select all patients over 65 years old. Then among them, the investigators report : * Antidepressants use by class (Non-selective monoamine reuptake inhibitors, Selective serotonin reuptake inhibitors, Selective serotonin-norepinephrine reuptake Inhibitors, Alpha-2-adrenergic receptor antagonists, Monoamine oxidase inhibitors, other antidepressants) * Delirium event * Co-prescription (Opioids, Antipsychotics, Anxiolytics, Hynotics) * Comorbidities (Constipation, acute retention of urine, hyponatraemia etc...)
Analysis of the association between antidepressant classes and delirium reporting, among subjects aged 65 or older
时间窗: 03/01/2022
A disproportionality analysis is carried out in multivariate analysis, taking into account a certain number of confounding factors (co-prescriptions and comorbidities)
次要结局
- Analysis by age group(03/01/2022)
- Analysis of the co-reporting of delirium and hyponatraemia(03/01/2022)
- Analysis of the most prescribed antidepressant(03/01/2022)