Effect of Intraoperative Music on Inflammatory Response in Adult Living Donor Hepatectomy.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 61
- 试验地点
- 1
- 主要终点
- Differences in Interleukin-6 (IL-6)
研究概览
简要总结
It has been reported that non-pharmacological methods can be used as an alternative in addition to pharmacological methods to reduce pain, anxiety, stress and inflammatory response that begins with the surgical incision in the intraoperative period and continues throughout the operation. It has been reported that music can be used as an alternative non-pharmacological method to reduce pain and anxiety in the perioperative period, as well as surgical stress and the related stress response.
The aim of this study is to test the hypothesis that music used as a non-pharmacological method in the intraoperative period can reduce inflammatory response in living donor hepatectomy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing donor hepatectomy
- •American Society of Anesthesiologists class 1 to 2
- •Ability to consent
排除标准
- •American Society of Anesthesiologists greater than 2
- •Documented or known sensitivity to any drug to be used in the study.
- •Patient with immunosuppressant/ cytotoxic/ steroid therapy.
- •not understand the aim and objectives of the study
结局指标
主要结局
Differences in Interleukin-6 (IL-6)
时间窗: 4 hours
Serum levels of IL-6 will be measured preoperatively and postoperatively.
次要结局
- Difference between serum levels of total antioxidant capacity (TAC) at preoperative and postoperative period.(4 hours)
- Difference in tumor necrosis factor alpha (TNF-alfa)(4 hours)
- Differences in preoperative State-Trait Anxiety Inventory scores(20 minutes)
- Difference between serum levels of total oxidant capacity (TOC) at preoperative and postoperative period.(4 hours)
- Difference in c-reactive protein (CRP)(24 hours)
- Difference in alanine aminotransferase (ALT)(24 hours)
- Difference in creatinine(24 hours)
- Differences in pain scores(24 hours)
- Difference in aspartate aminotransferase (AST)(24 hours)
- Differences in postoperative State-Trait Anxiety Inventory scores(20 minutes)