The Association Between Parathyroid Hormone and Preterm Labor
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- parathyroid hormone
研究概览
简要总结
This observational study aims to test the level of parathyroid hormone in pregnant women. The main question it aims to answer is:
n Pregnant women, are the levels of serum PTH, calcium, magnesium, phosphorus & albumin similar in both preterm and term births?
详细描述
- Approval from ethical committee will be sought.
- Patients will be enrolled from Ain Shams University Maternity Hospital labor ward and antenatal outpatient clinic.
- History, examination and fetal ultrasound will be done to identify eligible patients.
History: a full detailed history including personal, menstrual, obstetric, present, past history and family history will be obtained.
Accurate last menstrual period date will be obtained, and gestational age will be calculated using Naegele's rule or first trimester ultrasound to identify preterm patients with gestational age (28-36 weeks).
Examination: general, abdominal and vaginal examination to identify patients in established labor with Regular uterine contractions are at least 3 in 10 min each lasting 40 seconds. Progressive cervical dilatation (at least 4 cm). Ultrasound: for (viability of fetus, fetal biometry and estimated fetal weight, amniotic fluid, placental localization).
Thus, two groups of patients will be identified:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Pregnant women aged (18-40).
- •Gestational age (28-36 weeks).
排除标准
- •Known maternal disease as diabetes, hypertension, renal disease, cardiac disease and liver disease.
- •Known hypo or hyperparathyroidism
- •Multiple pregnancy
- •Polyhydramnios
- •Premature rupture of membrane
- •Antepartum Hemorrhage
- •Uterine malformations e.g. bicornuate uterus
结局指标
主要结局
parathyroid hormone
时间窗: 1 day
serum level of parathyroid hormone (ng/L)
次要结局
- Phosphorus(1 day)
- Albumin(1 day)
- Calcium(1 day)
- Magnesium(1 day)
研究者
Rania Hassan Mostafa
Principal Investigator
Ain Shams Maternity Hospital