The AIM-to-OBserve study: Adipokines and Inflammatory Markers in childhood OBesity - AIMOB

niversitair Medisch Centrum Utrecht0 个研究点目标入组 140 人开始时间: 待定最近更新: 2024年8月12日

适应症

试验速览

暂无简介。

•Patientgroup:
•6-16 years of age
•BMI (>30 kg/m2 projected at the age of18 years), according to international standards, see also Hirasing RA, Fredriks AM, van BS, Verloove-Vanhorick SP, Wit JM. [Increased prevalence of overweight and obesity in Dutch children, and the detection of overweight and obesity using international criteria and new reference diagrams]. Ned Tijdschr Geneeskd 2001 July 7;145(27):1303-8.;Controls:
•Sex and age matched to patient group
•-0.5 SD Newly referred patients to the pediatric outpatient department, by general practitioners, for the reason of:
•- Suspected allergy or asthma
•- Analysis of complaints of fatigue/malaise
•- Prediction of final height
•- Habitual constipation (i.e. constipation not explained by a disease)

•Patientgroup:
•- Intoxication (smoking, i.e. sigaret use, drug-use)
•- Acute illness (fever)
•- Mental retardation
•- Allergy with positive RAST for food/inhalation allergy and (history of) Muller class I-II reaction (i.e. severe systemic allergy/anaphylaxis)
•- Asthma (based on doctors* diagnosis: history of recurrent wheezing, obstructive
•lung function tests with reversibility after administration of β2-sympathicomimetics,
•use of asthma-medication)
•- Intoxication (smoking, drug-use)
•- Acute illness (fever)
•- Mental retardation
•Exclusion criteria for involved referrals:
•- Allergy with positive RAST for food/inhalation allergy and (history of) Muller class I-II reaction (i.e. severe systemic allergy/anaphylaxis)
•- Asthma (based on doctors* diagnosis: history of recurrent wheezing, obstructive lung function tests with reversibility after administration of β2-sympathicomimetics, use of asthma-medication)
•- Complaints of fatigue/malaise explained by M.Pfeiffer, inflammatory or infectious illness (e.g. inflammatory bowel disease, (viral) hepatitis, rheumatologic disease)
•- Assessment of height when short or tall stature (height ± 1 SD of target height (TH), so height outside TH-range) or endocrine explanation for abnormal growth pattern (e.g. growth hormone deficiency)
•The exclusion-criteria are formulated on the assumption that these might influence adipokine/inflammatory profiles.

发起方

niversitair Medisch Centrum Utrecht