Adipose tissue and systemic inflammation; exploring the roles of C3 and vitamin D

Recruiting

• Conditions: Morbide obesitas; excessive body weight; Morbid obesity; 10018424; 10003216

• Registration Number: NL-OMON41204
• Lead Sponsor: Sint Franciscus Gasthuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 220

Inclusion Criteria

Scheduled for bariatric surgery (which means BMI >40 or BMI>35 with comorbidity)
Scheduled for laparoscopic cholecystectomy (BMI <30)
Aged 18 or above
Given Informed consent

Exclusion Criteria

Previous cholecystectomy
Any acute inflammatory disease within 6 weeks prior to surgery
Any immune modulating therapy within 6 weeks prior to surgery
Patients planned for bariatric surgery and cholecystectomy 'en bloc'
Patients unable to understand and/or read the given information

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To analyze the effect of weight loss on the relationship between concentrations<br /><br>of C3 and vitamin D in visceral and subcutaneous adipose tissue and serum.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To analyze the relation of vitamin D and C3 with general markers of<br /><br>inflammation and classic cardiovascular risk factors in adipose tissue and<br /><br>serum and to analyze the effects of weight loss on these relations. To<br /><br>investigate acute changes in post-operative serum C3 levels in obese and<br /><br>non-obese subjects.</p><br>