NCT00510705终止不适用
Chronic Inflammatory Activation in Fat Tissue: An Atherogenic Factor in Severe Coronary Artery Disease
University of Leipzig2 个研究点 分布在 1 个国家目标入组 29 人开始时间: 2007年7月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 29
- 试验地点
- 2
- 主要终点
- change in endothelial function in severe coronary artery disease
研究概览
简要总结
Chronic inflammatory activation in fat tissue can be the link between adiposity and an increased risk for atherosclerosis. The aim of this study is to investigate how molecular alterations in fat tissue can be influenced by regular physical exercise training alone or in combination with a medical therapy (glitazone or metformin) in obese patients with severe coronary artery disease (CAD) and impaired glucose tolerance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Either impaired glucose tolerance (2 hour plasma glucose concentration > 7.8 and < 11.1 mmol/L during an oral glucose tolerance test) or impaired fasting plasma glucose concentration ( > 6.0 and < 7.0 mmol/L)
- •Body mass index (BMI) > 25
- •Severe coronary artery disease determined by coronary angiography
- •Male patients aged 35-75 years
排除标准
- •Diabetes mellitus type I
- •Diabetes mellitus type II in combination with glycosylates hemoglobin > 6.0%, previous medication with oral antidiabetic agents or insulin, fasting plasma glucose concentration > 11.0 mmol/L
- •Unstable angina pectoris
- •Myocardial infarction within the last 4 weeks
- •Reduced left-ventricular systolic function < 30%
结局指标
主要结局
change in endothelial function in severe coronary artery disease
时间窗: 4 weeks
次要结局
- change in metabolic parameters(4 weeks)
研究者
Axel Linke
Co-Investigator
University of Leipzig
研究点 (2)
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