Nantes Bariatric Surgery Cohort
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Observe how biological age evolves between pre-bariatric surgery and 1 year after bariatric surgery
研究概览
简要总结
While current research suggests that inflammation of adipose tissue in obesity is linked to accelerated aging, it has yet to be determined in humans how this could enhance preventative and personalized medicine for obese individuals. The NBC study aims to investigate :
- Whether bariatric surgery is associated with changes in biological age
- If bariatric surgery alters adipocyte dysfunction, the microbiota and biological rhythms
- Whether changes in adipocyte dysfunction, microbiota and biological rhythms are linked to changes in biological age.
To achieve this, establishing a biocollection before, during and after bariatric surgery will be crucial in addressing these questions
详细描述
The study of the Nantes Bariatric Surgery Cohort (NBC) aims to evaluate the impact of bariatric surgery on biological age, adipocyte dysfunction, microbiota, and biological rhythms in individuals with obesity. This observational study will include 300 participants over 3.5 years. It involves pre-operative, peri-operative, and post-operative visits to collect clinical, biological, and lifestyle data. Key assessments include anthropometrics, blood tests, questionnaires, and biocollections
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Individuals selected for bariatric surgery (starting the BC pathway within the Nantes University Hospital bariatric unit). Inclusion criteria are those of the Bariatric Surgery program.
- •male or female, adult over 18 years of age
- •BMI ≥ 35 kg/m2 with complication(s) or ≥ 40 kg/m2 with or without complication (the list of eligible complications is referenced in HAS 2024 recommendations). In the event of a change in access to bariatric surgery, this threshold could be revised without any substantial change to the protocol.
- •having consented to their participation in the cohort
- •participant affiliated to or benefiting from a social security scheme
排除标准
- •Persons protected by law (guardianship or trusteeship) or deprived of their freedom,
- •Pregnant women (contraindication to CB) or nursing mothers.
研究组 & 干预措施
observation of the change in biological age after bariatric surgery
Patients over 18 years of age suffering from obesity and requiring bariatric surgery.
Evolution of biological age 1 year after surgery, defined by the difference between age biological at TPO and TAC 1 year, estimated by measuring the phenotypic age, itself determined from the following eight variables: albumin; creatinine; fasting blood sugar; CRP
; lymphocyte count; mean corpuscular volume of red blood cells; Anisocytosis index of red blood cells; alkaline phosphatases; leukocyte rate.
干预措施: Nantes bariatric surgery cohort (Other)
结局指标
主要结局
Observe how biological age evolves between pre-bariatric surgery and 1 year after bariatric surgery
时间窗: 1 year
Biological age will be estimated by measuring phenotypic age. The phenotypic age will be determined from the following variable: albumin, creatinine, fasting glucose, CRP, lymphocyte count, red cell size, alkaline phosphates, leukocyte count.
次要结局
未报告次要终点