Sensorimotor Basis of Speech Motor Learning and Retention
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Retention of learning
研究概览
简要总结
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.
详细描述
The focus of this registration is Aim 3. Excitability will be assessed. In Aim 3, resting-state fMRI will be interleaved with speech motor adaptation, again using Harvard Sentences. Additional scans and retention tests will be conducted 24 hours later, to assess motor memory consolidation.
The Speech Motor Learning and Retention Master Protocol is NCT06467292.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Fluent English speakers
- •Right-handed
- •Normal hearing
- •No speech disorder or reading disability
排除标准
- •Cardiac pacemaker
- •Aneurysm clip
- •Heart or Vascular clip
- •Prosthetic valve
- •Metal implants
- •Metal in brain, skull, or spinal cord
- •Implanted neurostimulator
- •Medication infusion device
- •Cochlear implant or tinnitus (ringing in ears)
- •Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
- •Psychoactive medications
- •Pregnancy
研究组 & 干预措施
Altered auditory feedback + fMRI
Participants will perform learning tasks then undergo fMRI. This procedure will be repeated on day 2. Functional connectivity patterns between regions that predict learning will be assessed. Participants then leave the laboratory and return 24 hours later to assess retention of learning.
干预措施: Adaptation (Behavioral)
Altered auditory feedback + fMRI
Participants will perform learning tasks then undergo fMRI. This procedure will be repeated on day 2. Functional connectivity patterns between regions that predict learning will be assessed. Participants then leave the laboratory and return 24 hours later to assess retention of learning.
干预措施: fMRI (Device)
Control Condition
Participants in a control condition who will undergo the same procedures, without altered feedback
干预措施: fMRI (Device)
Control Condition
Participants in a control condition who will undergo the same procedures, without altered feedback
干预措施: Adaptation (Behavioral)
结局指标
主要结局
Retention of learning
时间窗: 24 hours after learning (re-test lasts 30 minutes)
The retention of adaptation to altered auditory feedback (and relearning) will be quantified in terms of F1 and F2 frequency shifts (relative to pre-training baseline). Larger values indicate more complete relearning or retention.
Change in fMRI resting-state connectivity following speech motor learning
时间窗: baseline and at the end of learning (30 minute session)
fMRI resting-state connectivity change following speech motor learning. Functional connectivity will be measured between each of the following regions: Heschel's gyrus, posterior superior temporal gyrus, primary and second somatosensory cortex, supramarginal gyrus, inferior frontal gyrus, motor and ventral premotor cortex and supplementary motor area.
Speech motor learning
时间窗: Performance as measured at the end of learning (30 minute session)
Audapter software will be used to alter the first and second formant frequencies of the spoken words and this is played back to subjects through headphones. Subjects will be tested both with unaltered feedback and with abruptly introduced frequency shifts.The change in the first (F1) and second format frequency (F2) values will be assessed using Praat.
fMRI resting-state connectivity measures of motor memory retention
时间窗: 24 hours after learning (re-test lasts 30 minutes)
fMRI resting-state connectivity measures of motor memory retention. Functional connectivity will be measured between each of the following regions: Heschel's gyrus, posterior superior temporal gyrus, primary and second somatosensory cortex, supramarginal gyrus, inferior frontal gyrus, motor and ventral premotor cortex and supplementary motor area.
次要结局
未报告次要终点