Expression of FosB Gene in Laryngeal Cancer Tissues and It's Clinical Prognosis Significance
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined.
研究概览
简要总结
To determine whether there is statisstical difference in FosB (FBJ murine osteosarcoma viral oncogene homolog B) protein expression between laryngeal cancer tissue and adjacent tissue through immunohistochemistry methods.
If there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. ultimately analyze whether it is related to the expression of FOsB in laryngeal cancer tissue and adjacent tissues
详细描述
First,the investigators will collect 100 to 200 cases of laryngeal cancer patients who have been finally diagnosed and treated in our institution in the past five years. Laryngeal cancer pathological tissues and adjacent tissues will be selected to make pathological sections. Use immunohistochemistry to confirm the differences in FosB protein between laryngeal cancer tissues and adjacent tissues, and clarify whether there are differences.
secondly,if there are differences, further the investigators will collect relevant patients information,such as clinical stages, pathological types, clinical prognosis and so on. Review the clinical data of corresponding patients, including age, gender, smoking and alcohol history, clinical stages, pathological types and clinical prognosis, etc., and compare whether there are statistical differences.
Finally, clinical prognostic data of relevant patients were collected through outpatient follow-up, online and telephone follow-up, to determine whether there is a correlation between Fosb expression in laryngeal cancer tissue and clinical prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 35 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •laryngeal squamous cell carcinoma was diagnosed ,and biopsy was confirmed by two pathologists;
- •Primary tumor of Laryngeal ,and there was no distant metastasis;
- •Standard treatment such as surgery and Preliminarily-diagnosed parients;
- •full clinical and pathological data information and good follow-up;
- •there was no previous fatal diseases such as complicated tumors.
排除标准
- •Secondary cancer or cancer with distant metastasis;
- •Patients who have not seen a doctor for the first time or have received surgery or radiotherapy or chemotherapy in other hospitals;
- •Clinical and pathological data were missing and loss to follow-up;
- •Patients who abandoned treatment or standard treatment procedures has not been completed;
- •The past medical history of other lethal diseases such as complicated tumors.
结局指标
主要结局
the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined.
时间窗: one month
the number of fosb gene positive expression cases in laryngeal carcinoma cells and adjacent tissues was determined by immunohistochemical test of pathological sections.
次要结局
- _Experimental result of western blot and PCR._Correlation analysis data between clinical information and experimental results..(three months)
研究者
Yang ji
associate professor
Neijiang No.2 People's Hospital